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- NCIT_C165649 IAO_0000115 "A dietary supplement composed of dried egg yolk powder that is highly enriched in the protein anti-secretory factor (AF), with anti-inflammatory, anti-diarrheal, immunomodulating and chemo-adjuvant activities. Upon intratumoral administration of the AF-enriched egg yolk powder supplement, AF is able to normalize fluid flow by regulating the ion and fluid balance across the cell membranes, and decreases high interstitial fluid pressure (IFP). As elevated IFP presents a barrier to drug uptake and poor perfusion in solid tumors, reducing IFP levels allows for increased uptake and an enhanced effect of chemotherapeutic agents. In addition, AF may be able to modulate the immune system and may have immunomodulatory effects on myeloid cells. It may also modulate the secretion of immunomodulatory agents from tumor cells. In addition, AF may affect the secretion of various pro-inflammatory mediators such as interleukin-6 (IL-6), IL-8, monocyte chemotactic protein-1 (MCP-1; monocyte chemoattractant protein-1; C-C Motif Chemokine Ligand 2; CCL2), macrophage inflammatory protein-1alpha (MIP-1a), and macrophage inflammatory protein-1beta (MIP-1b). AF, a 41 kilodalton (kDa) endogenous and essential protein secreted in plasma and other tissue fluids in mammals, is increased after exposure to bacterial toxins and endogenous triggers of inflammation." @default.
- NCIT_C165649 NCIT_NHC0 "C165649" @default.
- NCIT_C165649 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C165649 NCIT_P108 "Antisecretory Factor-enriched Egg Yolk Powder Supplement" @default.
- NCIT_C165649 NCIT_P208 "CL978952" @default.
- NCIT_C165649 NCIT_P329 "799798" @default.
- NCIT_C165649 NCIT_P330 "799798" @default.
- NCIT_C165649 NCIT_P399 "799798" @default.
- NCIT_C165649 normalizedInformationContent "100" @default.
- NCIT_C165649 referenceCount "1" @default.
- NCIT_C165649 hasExactSynonym "AF-enriched Egg Yolk Powder Supplement" @default.
- NCIT_C165649 hasExactSynonym "Antisecretory Factor-enriched Egg Yolk Powder Supplement" @default.
- NCIT_C165649 hasExactSynonym "Salovum" @default.
- NCIT_C165649 inSubset NCIT_C128784 @default.
- NCIT_C165649 inSubset NCIT_C176424 @default.
- NCIT_C165649 type Class @default.
- NCIT_C165649 isDefinedBy ncit.owl @default.
- NCIT_C165649 label "Antisecretory Factor-enriched Egg Yolk Powder Supplement" @default.
- NCIT_C165649 subClassOf NCIT_C1505 @default.
- NCIT_C165649 subClassOf NCIT_C165649 @default.
- NCIT_C165649 subClassOf NCIT_C1908 @default.