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- NCIT_C165656 IAO_0000115 "A human bispecific antibody directed against the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and another directed against the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-BCMA/anti-CD3 bispecific antibody REGN5459 binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and BCMA on BCMA-expressing tumor cells. This activates and redirects CTLs to BCMA-expressing tumor cells, leading to CTL-mediated killing of BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival." @default.
- NCIT_C165656 NCIT_A32 NCIT_C1909 @default.
- NCIT_C165656 NCIT_A7 NCIT_C97848 @default.
- NCIT_C165656 NCIT_NHC0 "C165656" @default.
- NCIT_C165656 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C165656 NCIT_P107 "Anti-BCMA/Anti-CD3 Bispecific Antibody REGN5459" @default.
- NCIT_C165656 NCIT_P108 "Anti-BCMA/Anti-CD3 Bispecific Antibody REGN5459" @default.
- NCIT_C165656 NCIT_P208 "CL978958" @default.
- NCIT_C165656 NCIT_P322 "CTRP" @default.
- NCIT_C165656 NCIT_P322 "GDC" @default.
- NCIT_C165656 NCIT_P329 "800119" @default.
- NCIT_C165656 NCIT_P330 "800119" @default.
- NCIT_C165656 NCIT_P375 "Anti-BCMA/Anti-CD3 Bispecific Antibody REGN5459" @default.
- NCIT_C165656 NCIT_P399 "800119" @default.
- NCIT_C165656 NCIT_R124 NCIT_C17710 @default.
- NCIT_C165656 NCIT_R124 NCIT_C17828 @default.
- NCIT_C165656 NCIT_R124 NCIT_C18219 @default.
- NCIT_C165656 NCIT_R124 NCIT_C19986 @default.
- NCIT_C165656 NCIT_R124 NCIT_C40474 @default.
- NCIT_C165656 normalizedInformationContent "100" @default.
- NCIT_C165656 referenceCount "1" @default.
- NCIT_C165656 hasExactSynonym "Anti-BCMA x Anti-CD3 Bispecific Antibody REGN5459" @default.
- NCIT_C165656 hasExactSynonym "Anti-BCMA/Anti-CD3 Bispecific Antibody REGN5459" @default.
- NCIT_C165656 hasExactSynonym "Anti-BCMA/CD3 Bispecific Antibody REGN5459" @default.
- NCIT_C165656 hasExactSynonym "Anti-CD3/Anti-BCMA Bispecific Antibody REGN5459" @default.
- NCIT_C165656 hasExactSynonym "REGN 5459" @default.
- NCIT_C165656 hasExactSynonym "REGN-5459" @default.
- NCIT_C165656 hasExactSynonym "REGN5459" @default.
- NCIT_C165656 inSubset NCIT_C116977 @default.
- NCIT_C165656 inSubset NCIT_C116978 @default.
- NCIT_C165656 inSubset NCIT_C128784 @default.
- NCIT_C165656 inSubset NCIT_C157711 @default.
- NCIT_C165656 inSubset NCIT_C157712 @default.
- NCIT_C165656 inSubset NCIT_C176424 @default.
- NCIT_C165656 inSubset NCIT_C177537 @default.
- NCIT_C165656 type Class @default.
- NCIT_C165656 isDefinedBy ncit.owl @default.
- NCIT_C165656 label "Anti-BCMA/Anti-CD3 Bispecific Antibody REGN5459" @default.
- NCIT_C165656 subClassOf NCIT_C112883 @default.
- NCIT_C165656 subClassOf NCIT_C129821 @default.
- NCIT_C165656 subClassOf NCIT_C129822 @default.
- NCIT_C165656 subClassOf NCIT_C1454 @default.
- NCIT_C165656 subClassOf NCIT_C163758 @default.
- NCIT_C165656 subClassOf NCIT_C165656 @default.
- NCIT_C165656 subClassOf NCIT_C181111 @default.
- NCIT_C165656 subClassOf NCIT_C181113 @default.
- NCIT_C165656 subClassOf NCIT_C181114 @default.
- NCIT_C165656 subClassOf NCIT_C1908 @default.
- NCIT_C165656 subClassOf NCIT_C1909 @default.
- NCIT_C165656 subClassOf NCIT_C201282 @default.
- NCIT_C165656 subClassOf NCIT_C20401 @default.
- NCIT_C165656 subClassOf NCIT_C274 @default.
- NCIT_C165656 subClassOf NCIT_C28227 @default.
- NCIT_C165656 subClassOf NCIT_C307 @default.
- NCIT_C165656 subClassOf NCIT_C308 @default.