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- NCIT_C165657 IAO_0000115 "An antibody-drug conjugate (ADC) composed of OBI-888 (OBI 888), a humanized monoclonal antibody directed against the tumor-associated antigen (TAA) globohexaosylceramide (globo H), covalently linked to monomethyl auristatin E (MMAE), an auristatin derivative and a potent microtubule disrupting agent, with potential antineoplastic activity. Upon administration of anti-globo H/MMAE ADC OBI 999, the antibody moiety of OBI 999, OBI 888, targets and binds to globo H on tumor cells and is rapidly internalized, thereby delivering MMAE intracellularly. Upon proteolytic cleavage, MMAE targets and binds to tubulin and inhibits its polymerization, resulting in G2/M checkpoint arrest and apoptosis in globo H-expressing tumor cells. Globo H, a hexasaccharide glycosphingolipid, is (over)expressed on the surface of many types of tumor cells. Globo H is minimally or not expressed on healthy, normal cells; its expression on cancer cells is associated with increased proliferation and poor prognosis." @default.
- NCIT_C165657 NCIT_A32 NCIT_C1909 @default.
- NCIT_C165657 NCIT_A7 NCIT_C126893 @default.
- NCIT_C165657 NCIT_NHC0 "C165657" @default.
- NCIT_C165657 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C165657 NCIT_P107 "Anti-Globo H/MMAE Antibody-drug Conjugate OBI 999" @default.
- NCIT_C165657 NCIT_P108 "Anti-Globo H/MMAE Antibody-drug Conjugate OBI 999" @default.
- NCIT_C165657 NCIT_P208 "CL978959" @default.
- NCIT_C165657 NCIT_P322 "CTRP" @default.
- NCIT_C165657 NCIT_P322 "GDC" @default.
- NCIT_C165657 NCIT_P329 "800120" @default.
- NCIT_C165657 NCIT_P330 "800120" @default.
- NCIT_C165657 NCIT_P375 "Anti-Globo H/MMAE Antibody-drug Conjugate OBI 999" @default.
- NCIT_C165657 NCIT_P399 "800120" @default.
- NCIT_C165657 normalizedInformationContent "100" @default.
- NCIT_C165657 referenceCount "1" @default.
- NCIT_C165657 hasExactSynonym "ADC OBI 999" @default.
- NCIT_C165657 hasExactSynonym "Anti-Globo H/MMAE ADC OBI 999" @default.
- NCIT_C165657 hasExactSynonym "Anti-Globo H/MMAE Antibody-drug Conjugate OBI 999" @default.
- NCIT_C165657 hasExactSynonym "OBI 999" @default.
- NCIT_C165657 hasExactSynonym "OBI-888/MMAE ADC OBI-999" @default.
- NCIT_C165657 hasExactSynonym "OBI-999" @default.
- NCIT_C165657 hasExactSynonym "OBI999" @default.
- NCIT_C165657 inSubset NCIT_C116977 @default.
- NCIT_C165657 inSubset NCIT_C116978 @default.
- NCIT_C165657 inSubset NCIT_C128784 @default.
- NCIT_C165657 inSubset NCIT_C157711 @default.
- NCIT_C165657 inSubset NCIT_C157712 @default.
- NCIT_C165657 inSubset NCIT_C176424 @default.
- NCIT_C165657 inSubset NCIT_C177537 @default.
- NCIT_C165657 type Class @default.
- NCIT_C165657 isDefinedBy ncit.owl @default.
- NCIT_C165657 label "Anti-Globo H/MMAE Antibody-drug Conjugate OBI 999" @default.
- NCIT_C165657 subClassOf NCIT_C129821 @default.
- NCIT_C165657 subClassOf NCIT_C129823 @default.
- NCIT_C165657 subClassOf NCIT_C1512 @default.
- NCIT_C165657 subClassOf NCIT_C165657 @default.
- NCIT_C165657 subClassOf NCIT_C1908 @default.
- NCIT_C165657 subClassOf NCIT_C1909 @default.
- NCIT_C165657 subClassOf NCIT_C274 @default.
- NCIT_C165657 subClassOf NCIT_C307 @default.
- NCIT_C165657 subClassOf NCIT_C308 @default.
- NCIT_C165657 subClassOf NCIT_C575 @default.