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- NCIT_C165747 IAO_0000115 "An orally bioavailable inhibitor of cyclin-dependent kinases 8 and 19 (CDK8/19), with potential antineoplastic and chemoprotective activities. Upon oral administration, CDK8/19 inhibitor SEL 120 targets, binds to and inhibits the activity of CDK8/19, which prevents activation of CDK8/19-mediated oncogenic signaling pathways, blocks selective transcription of various tumor-promoting genes, and inhibits proliferation of CDK8/19-overexpressing tumor cells. CDK8/19, serine/threonine kinases involved in the regulation of the cell cycle, are overexpressed in certain cancer cell types and play key roles in tumor cell proliferation." @default.
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- NCIT_C165747 NCIT_P106 "Organic Chemical" @default.
- NCIT_C165747 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C165747 NCIT_P107 "CDK8/19 Inhibitor SEL 120" @default.
- NCIT_C165747 NCIT_P108 "CDK8/19 Inhibitor SEL 120" @default.
- NCIT_C165747 NCIT_P208 "CL978865" @default.
- NCIT_C165747 NCIT_P210 "1429515-59-2" @default.
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- NCIT_C165747 referenceCount "1" @default.
- NCIT_C165747 hasExactSynonym "CDK8/19 Inhibitor SEL 120" @default.
- NCIT_C165747 hasExactSynonym "SEL 120" @default.
- NCIT_C165747 hasExactSynonym "SEL 120-34" @default.
- NCIT_C165747 hasExactSynonym "SEL 120-34A" @default.
- NCIT_C165747 hasExactSynonym "SEL-120" @default.
- NCIT_C165747 hasExactSynonym "SEL120" @default.
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- NCIT_C165747 type Class @default.
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- NCIT_C165747 label "CDK8/19 Inhibitor SEL 120" @default.
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