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- NCIT_C165776 IAO_0000115 "An orally bioavailable protein-protein interaction (PPI) inhibitor of the menin-mixed lineage leukemia (MLL; myeloid/lymphoid leukemia; KMT2A) proteins, with potential antineoplastic activity. Upon oral administration, revumenib targets and binds to the nuclear protein menin, thereby preventing the interaction between the two proteins menin and MLL and the formation of the menin-MLL complex. This reduces the expression of downstream target genes and results in an inhibition of the proliferation of MLL-rearranged leukemic cells. The menin-MLL complex plays a key role in the survival, growth, transformation and proliferation of certain kinds of leukemia cells." @default.
- NCIT_C165776 NCIT_A32 NCIT_C1909 @default.
- NCIT_C165776 NCIT_A7 NCIT_C17595 @default.
- NCIT_C165776 NCIT_A7 NCIT_C18051 @default.
- NCIT_C165776 NCIT_NHC0 "C165776" @default.
- NCIT_C165776 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C165776 NCIT_P107 "Revumenib" @default.
- NCIT_C165776 NCIT_P108 "Revumenib" @default.
- NCIT_C165776 NCIT_P208 "CL978854" @default.
- NCIT_C165776 NCIT_P210 "2169919-21-3" @default.
- NCIT_C165776 NCIT_P319 "LZ0M43NNF2" @default.
- NCIT_C165776 NCIT_P322 "CTRP" @default.
- NCIT_C165776 NCIT_P322 "FDA" @default.
- NCIT_C165776 NCIT_P322 "GDC" @default.
- NCIT_C165776 NCIT_P329 "800199" @default.
- NCIT_C165776 NCIT_P330 "800199" @default.
- NCIT_C165776 NCIT_P375 "Menin-MLL Interaction Inhibitor SNDX-5613" @default.
- NCIT_C165776 NCIT_P399 "800199" @default.
- NCIT_C165776 normalizedInformationContent "100" @default.
- NCIT_C165776 referenceCount "1" @default.
- NCIT_C165776 hasExactSynonym "Benzamide, N-ethyl-2-((4-(7-((trans-4-((ethylsulfonyl)amino)cyclohexyl)methyl)-2,7-diazaspiro(3.5)non-2-yl)-5-pyrimidinyl)oxy)-5-fluoro-N-(1-methylethyl)-" @default.
- NCIT_C165776 hasExactSynonym "Menin-MLL Inhibitor SNDX-5613" @default.
- NCIT_C165776 hasExactSynonym "Menin-MLL Interaction Inhibitor SNDX-5613" @default.
- NCIT_C165776 hasExactSynonym "Menin-Mixed Lineage Leukemia Protein-Protein Interaction Inhibitor SNDX-5613" @default.
- NCIT_C165776 hasExactSynonym "REVUMENIB" @default.
- NCIT_C165776 hasExactSynonym "Revumenib" @default.
- NCIT_C165776 hasExactSynonym "SNDX 5613" @default.
- NCIT_C165776 hasExactSynonym "SNDX-5613" @default.
- NCIT_C165776 hasExactSynonym "SNDX5613" @default.
- NCIT_C165776 inSubset NCIT_C116977 @default.
- NCIT_C165776 inSubset NCIT_C116978 @default.
- NCIT_C165776 inSubset NCIT_C128784 @default.
- NCIT_C165776 inSubset NCIT_C157711 @default.
- NCIT_C165776 inSubset NCIT_C157712 @default.
- NCIT_C165776 inSubset NCIT_C176424 @default.
- NCIT_C165776 inSubset NCIT_C177537 @default.
- NCIT_C165776 inSubset NCIT_C63923 @default.
- NCIT_C165776 type Class @default.
- NCIT_C165776 isDefinedBy ncit.owl @default.
- NCIT_C165776 label "Revumenib" @default.
- NCIT_C165776 subClassOf NCIT_C165776 @default.
- NCIT_C165776 subClassOf NCIT_C185877 @default.
- NCIT_C165776 subClassOf NCIT_C1908 @default.
- NCIT_C165776 subClassOf NCIT_C1909 @default.
- NCIT_C165776 subClassOf NCIT_C2189 @default.
- NCIT_C165776 subClassOf NCIT_C274 @default.