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- NCIT_C165778 IAO_0000115 "A blood-brain-barrier (BBB) penetrable selective inhibitor of epidermal growth factor receptor (EGFR) and various EGFR mutations, including but not limited to the EGFR variant III (EGFRvIII) mutant form, with potential antineoplastic activity. Upon administration of EGFR/EGFRvIII inhibitor WSD0922-FU, this agent is able to penetrate the BBB and specifically targets, binds to and inhibits EGFR and specific EGFR mutations, which prevents EGFR/EGFR mutant-mediated signaling and leads to cell death in EGFR/EGFR mutant-expressing tumor cells. Compared to other EGFR inhibitors that are not able to penetrate the BBB, WSD0922-FU may have therapeutic benefits in brain tumors, such as glioblastoma (GBM) and metastatic CNS tumors. EGFR, a receptor tyrosine kinase (RTK) that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and survival." @default.
- NCIT_C165778 NCIT_A32 NCIT_C1909 @default.
- NCIT_C165778 NCIT_A7 NCIT_C17068 @default.
- NCIT_C165778 NCIT_NHC0 "C165778" @default.
- NCIT_C165778 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C165778 NCIT_P107 "EGFR/EGFRvIII Inhibitor WSD0922-FU" @default.
- NCIT_C165778 NCIT_P108 "EGFR/EGFRvIII Inhibitor WSD0922-FU" @default.
- NCIT_C165778 NCIT_P208 "CL979063" @default.
- NCIT_C165778 NCIT_P322 "CTRP" @default.
- NCIT_C165778 NCIT_P322 "GDC" @default.
- NCIT_C165778 NCIT_P329 "800200" @default.
- NCIT_C165778 NCIT_P330 "800200" @default.
- NCIT_C165778 NCIT_P375 "EGFR/EGFRvIII Inhibitor WSD0922-FU" @default.
- NCIT_C165778 NCIT_P399 "800200" @default.
- NCIT_C165778 normalizedInformationContent "100" @default.
- NCIT_C165778 referenceCount "1" @default.
- NCIT_C165778 hasExactSynonym "BBB Penetrable EGFR/EGFRvIII Inhibitor WSD0922-FU" @default.
- NCIT_C165778 hasExactSynonym "EGFR Mutant Inhibitor WSD0922-FU" @default.
- NCIT_C165778 hasExactSynonym "EGFR/EGFRvIII Inhibitor WSD0922-FU" @default.
- NCIT_C165778 hasExactSynonym "WSD 0922-FU" @default.
- NCIT_C165778 hasExactSynonym "WSD-0922-FU" @default.
- NCIT_C165778 hasExactSynonym "WSD0922-FU" @default.
- NCIT_C165778 inSubset NCIT_C116977 @default.
- NCIT_C165778 inSubset NCIT_C116978 @default.
- NCIT_C165778 inSubset NCIT_C128784 @default.
- NCIT_C165778 inSubset NCIT_C157711 @default.
- NCIT_C165778 inSubset NCIT_C157712 @default.
- NCIT_C165778 inSubset NCIT_C176424 @default.
- NCIT_C165778 inSubset NCIT_C177537 @default.
- NCIT_C165778 type Class @default.
- NCIT_C165778 isDefinedBy ncit.owl @default.
- NCIT_C165778 label "EGFR/EGFRvIII Inhibitor WSD0922-FU" @default.
- NCIT_C165778 subClassOf NCIT_C129824 @default.
- NCIT_C165778 subClassOf NCIT_C129825 @default.
- NCIT_C165778 subClassOf NCIT_C1404 @default.
- NCIT_C165778 subClassOf NCIT_C163758 @default.
- NCIT_C165778 subClassOf NCIT_C163952 @default.
- NCIT_C165778 subClassOf NCIT_C165778 @default.
- NCIT_C165778 subClassOf NCIT_C1908 @default.
- NCIT_C165778 subClassOf NCIT_C1909 @default.
- NCIT_C165778 subClassOf NCIT_C1967 @default.
- NCIT_C165778 subClassOf NCIT_C2167 @default.
- NCIT_C165778 subClassOf NCIT_C2189 @default.
- NCIT_C165778 subClassOf NCIT_C274 @default.
- NCIT_C165778 subClassOf NCIT_C471 @default.