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- NCIT_C16602 IAO_0000115 "Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6. The regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia. (LocusLink)" @default.
- NCIT_C16602 NCIT_NHC0 "C16602" @default.
- NCIT_C16602 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C16602 NCIT_P106 "Enzyme" @default.
- NCIT_C16602 NCIT_P108 "Gamma-Glutamylcysteine Synthetase" @default.
- NCIT_C16602 NCIT_P207 "C0017037" @default.
- NCIT_C16602 NCIT_P366 "Gamma-Glutamylcysteine_Synthetase" @default.
- NCIT_C16602 NCIT_R52 NCIT_C16554 @default.
- NCIT_C16602 NCIT_R52 NCIT_C16796 @default.
- NCIT_C16602 NCIT_R52 NCIT_C17021 @default.
- NCIT_C16602 NCIT_R52 NCIT_C20027 @default.
- NCIT_C16602 NCIT_R52 NCIT_C26548 @default.
- NCIT_C16602 normalizedInformationContent "90.826665450122817" @default.
- NCIT_C16602 referenceCount "4" @default.
- NCIT_C16602 hasExactSynonym "EC 6.3.2.2" @default.
- NCIT_C16602 hasExactSynonym "Gamma-Glutamylcysteine Synthetase" @default.
- NCIT_C16602 hasExactSynonym "Gamma-Glutamylcysteinyl Synthetase" @default.
- NCIT_C16602 hasExactSynonym "Glutamate-Cysteine Ligase" @default.
- NCIT_C16602 type Class @default.
- NCIT_C16602 isDefinedBy ncit.owl @default.
- NCIT_C16602 label "Gamma-Glutamylcysteine Synthetase" @default.
- NCIT_C16602 subClassOf Bc2c6cb39167fc39ad810208b878b1e99 @default.
- NCIT_C16602 subClassOf Bc77e5f91f490661c0ad3ce67ffcdfd2a @default.
- NCIT_C16602 subClassOf NCIT_C16602 @default.
- NCIT_C16602 subClassOf NCIT_C21176 @default.
- NCIT_C16602 subClassOf NCIT_C26548 @default.