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- NCIT_C166177 IAO_0000115 "An orally bioavailable prodrug and influenza cap-dependent endonuclease (CEN) inhibitor, with antiviral activity. Upon administration of baloxavir marboxil, the agent is converted by hydrolysis to its active metabolite baloxavir. Baloxavir targets, binds to and inhibits the CEN activity of the influenza polymerase acidic (PA) protein, an influenza virus-specific enzyme in the viral RNA polymerase complex required for the initiation of influenza gene transcription. By inhibiting PA endonuclease, influenza virus mRNA replication is halted. This reduces viral load and prevents further influenza infection." @default.
- NCIT_C166177 NCIT_NHC0 "C166177" @default.
- NCIT_C166177 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C166177 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C166177 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C166177 NCIT_P107 "Baloxavir Marboxil" @default.
- NCIT_C166177 NCIT_P108 "Baloxavir Marboxil" @default.
- NCIT_C166177 NCIT_P208 "CL921178" @default.
- NCIT_C166177 NCIT_P210 "1985606-14-1" @default.
- NCIT_C166177 NCIT_P319 "505CXM6OHG" @default.
- NCIT_C166177 NCIT_P322 "CTRP" @default.
- NCIT_C166177 NCIT_P322 "FDA" @default.
- NCIT_C166177 NCIT_P329 "800205" @default.
- NCIT_C166177 NCIT_P330 "800205" @default.
- NCIT_C166177 NCIT_P399 "800205" @default.
- NCIT_C166177 normalizedInformationContent "100" @default.
- NCIT_C166177 referenceCount "1" @default.
- NCIT_C166177 hasExactSynonym "(((12aR)-12-((11S)-7,8-Difluoro-6,11-dihydrodibenzo(b,E)thiepin-11-yl)-6,8-dioxo-3,4,6,8,12,12ahexahydro-1H-(1,4)oxazino(3,4-C)pyrido(2,1-F)(1,2,4)triazin-7-yl)oxy)methyl Methyl Carbonate" @default.
- NCIT_C166177 hasExactSynonym "BALOXAVIR MARBOXIL" @default.
- NCIT_C166177 hasExactSynonym "BXM" @default.
- NCIT_C166177 hasExactSynonym "Baloxavir Marboxil" @default.
- NCIT_C166177 hasExactSynonym "Carbonic Acid, (((12aR)-12-((11S)-7,8-Difluoro-6,11-dihydrodibenzo(b,E)thiepin-11-yl)-3,4,6,8,12,12a-hexahydro-6,8-dioxo-1H-(1,4)oxazino(3,4-C)pyrido(2,1-F)(1,2,4)triazin-7-yl)oxy)methyl Methyl Ester" @default.
- NCIT_C166177 hasExactSynonym "Xofluza" @default.
- NCIT_C166177 inSubset NCIT_C116977 @default.
- NCIT_C166177 inSubset NCIT_C116978 @default.
- NCIT_C166177 inSubset NCIT_C176424 @default.
- NCIT_C166177 inSubset NCIT_C63923 @default.
- NCIT_C166177 type Class @default.
- NCIT_C166177 isDefinedBy ncit.owl @default.
- NCIT_C166177 label "Baloxavir Marboxil" @default.
- NCIT_C166177 subClassOf NCIT_C166177 @default.
- NCIT_C166177 subClassOf NCIT_C1908 @default.
- NCIT_C166177 subClassOf NCIT_C1909 @default.
- NCIT_C166177 subClassOf NCIT_C254 @default.
- NCIT_C166177 subClassOf NCIT_C281 @default.