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- NCIT_C166362 IAO_0000115 "A benzonapthyridine Toll-like receptor (TLR) 7 agonist that is adsorbed to aluminum hydroxide with immunostimulating and potential antitumor activities. Upon intratumoral administration of TLR7 agonist LHC165, the agent is slowly released and targets, binds to and activates TLR7. This may trigger, in addition to other possible responses, the activation of cluster of differentiation (CD) 8+ T cells and natural killer (NK) cells, the blockage of the suppressive function of regulatory T cells (Tregs), and the production of interferon alpha (IFNa). TLR7 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity." @default.
- NCIT_C166362 NCIT_A32 NCIT_C1909 @default.
- NCIT_C166362 NCIT_A7 NCIT_C30108 @default.
- NCIT_C166362 NCIT_NHC0 "C166362" @default.
- NCIT_C166362 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C166362 NCIT_P107 "TLR7 Agonist LHC165" @default.
- NCIT_C166362 NCIT_P108 "TLR7 Agonist LHC165" @default.
- NCIT_C166362 NCIT_P208 "CL971618" @default.
- NCIT_C166362 NCIT_P210 "1258595-14-0" @default.
- NCIT_C166362 NCIT_P319 "RD02U4QLM1" @default.
- NCIT_C166362 NCIT_P322 "CTRP" @default.
- NCIT_C166362 NCIT_P322 "FDA" @default.
- NCIT_C166362 NCIT_P322 "GDC" @default.
- NCIT_C166362 NCIT_P329 "800232" @default.
- NCIT_C166362 NCIT_P330 "800232" @default.
- NCIT_C166362 NCIT_P375 "TLR7 Agonist LHC165" @default.
- NCIT_C166362 NCIT_P399 "800232" @default.
- NCIT_C166362 normalizedInformationContent "100" @default.
- NCIT_C166362 referenceCount "1" @default.
- NCIT_C166362 hasExactSynonym "LHC 165" @default.
- NCIT_C166362 hasExactSynonym "LHC-165" @default.
- NCIT_C166362 hasExactSynonym "LHC165" @default.
- NCIT_C166362 hasExactSynonym "TLR7 Agonist LHC165" @default.
- NCIT_C166362 inSubset NCIT_C116977 @default.
- NCIT_C166362 inSubset NCIT_C116978 @default.
- NCIT_C166362 inSubset NCIT_C128784 @default.
- NCIT_C166362 inSubset NCIT_C157711 @default.
- NCIT_C166362 inSubset NCIT_C157712 @default.
- NCIT_C166362 inSubset NCIT_C176424 @default.
- NCIT_C166362 inSubset NCIT_C177537 @default.
- NCIT_C166362 inSubset NCIT_C63923 @default.
- NCIT_C166362 type Class @default.
- NCIT_C166362 isDefinedBy ncit.owl @default.
- NCIT_C166362 label "TLR7 Agonist LHC165" @default.
- NCIT_C166362 subClassOf NCIT_C166362 @default.
- NCIT_C166362 subClassOf NCIT_C177174 @default.
- NCIT_C166362 subClassOf NCIT_C177176 @default.
- NCIT_C166362 subClassOf NCIT_C1908 @default.
- NCIT_C166362 subClassOf NCIT_C1909 @default.
- NCIT_C166362 subClassOf NCIT_C2139 @default.
- NCIT_C166362 subClassOf NCIT_C308 @default.