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- NCIT_C166375 IAO_0000115 "An immunotherapeutic agent utilizing mRNA to encode the cytokines interleukin-12sc (IL-12sc), interleukin-15sushi (IL-15sushi), interferon alpha (IFNa) and granulocyte-macrophage colony-stimulating factor (GM-CSF), with potential immunomodulating and antineoplastic activities. Upon intratumoral administration of IL-12sc, IL-15sushi, IFNa and GM-CSF mRNA-based immunotherapeutic agent SAR441000, mRNA is picked up by nearby cells, translated and released into the local tumor microenvironment (TME). Secretion of these cytokines activate the immune system by promoting the activation of natural killer cells (NKs) and inducing cytotoxic T-lymphocyte (CTL) responses, which may result in an immune-mediated destruction of tumor cells." @default.
- NCIT_C166375 NCIT_A32 NCIT_C1909 @default.
- NCIT_C166375 NCIT_NHC0 "C166375" @default.
- NCIT_C166375 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C166375 NCIT_P107 "IL-12sc, IL-15sushi, IFNa and GM-CSF mRNA-based Immunotherapeutic Agent SAR441000" @default.
- NCIT_C166375 NCIT_P108 "IL-12sc, IL-15sushi, IFNa and GM-CSF mRNA-based Immunotherapeutic Agent SAR441000" @default.
- NCIT_C166375 NCIT_P208 "CL971627" @default.
- NCIT_C166375 NCIT_P322 "CTRP" @default.
- NCIT_C166375 NCIT_P322 "GDC" @default.
- NCIT_C166375 NCIT_P329 "800230" @default.
- NCIT_C166375 NCIT_P330 "800230" @default.
- NCIT_C166375 NCIT_P375 "IL-12sc, IL-15sushi, IFNa and GM-CSF mRNA-based Immunotherapeutic Agent SAR441000" @default.
- NCIT_C166375 NCIT_P399 "800230" @default.
- NCIT_C166375 normalizedInformationContent "100" @default.
- NCIT_C166375 referenceCount "1" @default.
- NCIT_C166375 hasExactSynonym "BNT 131" @default.
- NCIT_C166375 hasExactSynonym "BNT-131" @default.
- NCIT_C166375 hasExactSynonym "BNT131" @default.
- NCIT_C166375 hasExactSynonym "IL-12sc, IL-15sushi, IFNa and GM-CSF mRNA-based Immunotherapeutic Agent SAR441000" @default.
- NCIT_C166375 hasExactSynonym "SAR 441000" @default.
- NCIT_C166375 hasExactSynonym "SAR-441000" @default.
- NCIT_C166375 hasExactSynonym "SAR441000" @default.
- NCIT_C166375 inSubset NCIT_C116977 @default.
- NCIT_C166375 inSubset NCIT_C116978 @default.
- NCIT_C166375 inSubset NCIT_C128784 @default.
- NCIT_C166375 inSubset NCIT_C157711 @default.
- NCIT_C166375 inSubset NCIT_C157712 @default.
- NCIT_C166375 inSubset NCIT_C176424 @default.
- NCIT_C166375 inSubset NCIT_C177537 @default.
- NCIT_C166375 type Class @default.
- NCIT_C166375 isDefinedBy ncit.owl @default.
- NCIT_C166375 label "IL-12sc, IL-15sushi, IFNa and GM-CSF mRNA-based Immunotherapeutic Agent SAR441000" @default.
- NCIT_C166375 subClassOf NCIT_C129820 @default.
- NCIT_C166375 subClassOf NCIT_C166375 @default.
- NCIT_C166375 subClassOf NCIT_C1908 @default.
- NCIT_C166375 subClassOf NCIT_C1909 @default.
- NCIT_C166375 subClassOf NCIT_C1962 @default.
- NCIT_C166375 subClassOf NCIT_C274 @default.
- NCIT_C166375 subClassOf NCIT_C307 @default.
- NCIT_C166375 subClassOf NCIT_C308 @default.
- NCIT_C166375 subClassOf NCIT_C61199 @default.