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- NCIT_C166433 IAO_0000115 "The sodium salt form of guadecitabine, a dinucleotide antimetabolite composed of a decitabine linked via phosphodiester bond to a deoxyguanosine, with potential antineoplastic activity. Following metabolic activation via cleavage of the phosphodiester bond and incorporation of the decitabine moiety into DNA, guadecitabine inhibits DNA methyltransferase, thereby causing non-specific, genome-wide hypomethylation, and induction of cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, which may result in gradual release of decitabine both extra- and intra-cellularly, leading to prolonged exposure to decitabine." @default.
- NCIT_C166433 NCIT_NHC0 "C166433" @default.
- NCIT_C166433 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C166433 NCIT_P107 "Guadecitabine Sodium" @default.
- NCIT_C166433 NCIT_P108 "Guadecitabine Sodium" @default.
- NCIT_C166433 NCIT_P208 "CL971684" @default.
- NCIT_C166433 NCIT_P210 "929904-85-8" @default.
- NCIT_C166433 NCIT_P319 "0RB89YH367" @default.
- NCIT_C166433 NCIT_P322 "CTRP" @default.
- NCIT_C166433 NCIT_P322 "FDA" @default.
- NCIT_C166433 normalizedInformationContent "100" @default.
- NCIT_C166433 referenceCount "1" @default.
- NCIT_C166433 hasExactSynonym "GUADECITABINE SODIUM" @default.
- NCIT_C166433 hasExactSynonym "Guadecitabine Sodium" @default.
- NCIT_C166433 inSubset NCIT_C116977 @default.
- NCIT_C166433 inSubset NCIT_C116978 @default.
- NCIT_C166433 inSubset NCIT_C63923 @default.
- NCIT_C166433 type Class @default.
- NCIT_C166433 isDefinedBy ncit.owl @default.
- NCIT_C166433 label "Guadecitabine Sodium" @default.
- NCIT_C166433 subClassOf NCIT_C132686 @default.
- NCIT_C166433 subClassOf NCIT_C166433 @default.
- NCIT_C166433 subClassOf NCIT_C1908 @default.
- NCIT_C166433 subClassOf NCIT_C1909 @default.
- NCIT_C166433 subClassOf NCIT_C2083 @default.
- NCIT_C166433 subClassOf NCIT_C274 @default.
- NCIT_C166433 subClassOf NCIT_C471 @default.