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- NCIT_C166464 IAO_0000115 "An orally bioavailable, dual inhibitor of human C-C chemokine receptor types 2 (CCR2; CD192) and 5 (CCR5; CD195), with potential immunomodulating, anti-inflammatory and antiviral activities. Upon oral administration, cenicriviroc specifically binds to and prevents the activation of both CCR2 and CCR5. This inhibits the activation of CCR2/CCR5-mediated signal transduction pathways and may inhibit inflammatory processes. The G-protein coupled chemokine receptors CCR2 and CCR5 are expressed on the surface of monocytes and macrophages and stimulate their migration and infiltration; they play key roles in inflammation and autoimmune diseases. In addition, cenicriviroc inhibits human immunodeficiency virus (HIV)-1 entry via CCR5 coreceptor interaction." @default.
- NCIT_C166464 NCIT_NHC0 "C166464" @default.
- NCIT_C166464 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C166464 NCIT_P108 "Cenicriviroc" @default.
- NCIT_C166464 NCIT_P207 "C4279622" @default.
- NCIT_C166464 NCIT_P210 "497223-25-3" @default.
- NCIT_C166464 NCIT_P319 "15C116UA4Y" @default.
- NCIT_C166464 NCIT_P322 "FDA" @default.
- NCIT_C166464 normalizedInformationContent "100" @default.
- NCIT_C166464 referenceCount "1" @default.
- NCIT_C166464 hasExactSynonym "CENICRIVIROC" @default.
- NCIT_C166464 hasExactSynonym "CVC" @default.
- NCIT_C166464 hasExactSynonym "Cenicriviroc" @default.
- NCIT_C166464 inSubset NCIT_C173381 @default.
- NCIT_C166464 inSubset NCIT_C173383 @default.
- NCIT_C166464 inSubset NCIT_C63923 @default.
- NCIT_C166464 type Class @default.
- NCIT_C166464 isDefinedBy ncit.owl @default.
- NCIT_C166464 label "Cenicriviroc" @default.
- NCIT_C166464 subClassOf NCIT_C166464 @default.
- NCIT_C166464 subClassOf NCIT_C1908 @default.
- NCIT_C166464 subClassOf NCIT_C1909 @default.
- NCIT_C166464 subClassOf NCIT_C308 @default.
- NCIT_C166464 subClassOf NCIT_C63817 @default.