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- NCIT_C166608 IAO_0000115 "An orally bioavailable inhibitor of the innate immune signaling sensor nucleotide-binding domain and leucine-rich repeat (NLR) family pyrin domain containing 3 (NLRP3; NACHT, LRR and PYD containing protein 3; NALP3), with potential immunomodulatory and anti-inflammatory activities. Upon oral administration, dapansutrile specifically binds to and inhibits NLRP3, the sensor component of the NLRP3 inflammasome, and prevents the formation of the NLRP3 inflammasome. This inhibits the production of the pro-inflammatory cytokines interleukin-1-beta (IL-1beta) and interleukin-18 (IL-18), which may prevent or reduce inflammation. NLRP3 plays an important role in immunity and inflammation." @default.
- NCIT_C166608 NCIT_NHC0 "C166608" @default.
- NCIT_C166608 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C166608 NCIT_P107 "Dapansutrile" @default.
- NCIT_C166608 NCIT_P108 "Dapansutrile" @default.
- NCIT_C166608 NCIT_P208 "CL971857" @default.
- NCIT_C166608 NCIT_P210 "54863-37-5" @default.
- NCIT_C166608 NCIT_P319 "2Z03364G96" @default.
- NCIT_C166608 NCIT_P322 "CTRP" @default.
- NCIT_C166608 NCIT_P322 "FDA" @default.
- NCIT_C166608 NCIT_P399 "806040" @default.
- NCIT_C166608 normalizedInformationContent "100" @default.
- NCIT_C166608 referenceCount "1" @default.
- NCIT_C166608 hasExactSynonym "DAPANSUTRILE" @default.
- NCIT_C166608 hasExactSynonym "Dapansutrile" @default.
- NCIT_C166608 hasExactSynonym "OLT 1177" @default.
- NCIT_C166608 hasExactSynonym "OLT-1177" @default.
- NCIT_C166608 hasExactSynonym "OLT1177" @default.
- NCIT_C166608 inSubset NCIT_C116977 @default.
- NCIT_C166608 inSubset NCIT_C116978 @default.
- NCIT_C166608 inSubset NCIT_C173381 @default.
- NCIT_C166608 inSubset NCIT_C173383 @default.
- NCIT_C166608 inSubset NCIT_C176424 @default.
- NCIT_C166608 inSubset NCIT_C63923 @default.
- NCIT_C166608 type Class @default.
- NCIT_C166608 isDefinedBy ncit.owl @default.
- NCIT_C166608 label "Dapansutrile" @default.
- NCIT_C166608 subClassOf NCIT_C166608 @default.
- NCIT_C166608 subClassOf NCIT_C1908 @default.
- NCIT_C166608 subClassOf NCIT_C1909 @default.
- NCIT_C166608 subClassOf NCIT_C2198 @default.
- NCIT_C166608 subClassOf NCIT_C2356 @default.
- NCIT_C166608 subClassOf NCIT_C241 @default.
- NCIT_C166608 subClassOf NCIT_C257 @default.
- NCIT_C166608 subClassOf NCIT_C78272 @default.