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- NCIT_C166700 IAO_0000115 "The hydrochloride salt form of ozanimod, an orally bioavailable sphingosine-1-phosphate (S1P) receptors 1 (S1PR1, S1P1) and 5 (S1PR5, S1P5) modulator, with potential anti-inflammatory and immunomodulating activities. Upon oral administration, ozanimod selectively targets and binds to S1PR1 on lymphocytes and induces S1PR1 internalization and degradation. This results in the sequestration of lymphocytes in lymph nodes. By preventing egress of lymphocytes, ozanimod reduces both the amount of circulating peripheral lymphocytes and the infiltration of lymphocytes into target tissues. This prevents a lymphocyte-mediated immune response and may reduce inflammation. S1PR1, a G-protein coupled receptor, plays a key role in lymphocyte migration from lymphoid tissues. Modulation of S1PR5 by ozanimod may be neuroprotective." @default.
- NCIT_C166700 NCIT_A6 NCIT_C170279 @default.
- NCIT_C166700 NCIT_NHC0 "C166700" @default.
- NCIT_C166700 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C166700 NCIT_P108 "Ozanimod Hydrochloride" @default.
- NCIT_C166700 NCIT_P208 "CL971949" @default.
- NCIT_C166700 NCIT_P210 "1618636-37-5" @default.
- NCIT_C166700 NCIT_P319 "3UPR33JAAM" @default.
- NCIT_C166700 NCIT_P322 "FDA" @default.
- NCIT_C166700 NCIT_P399 "811939" @default.
- NCIT_C166700 normalizedInformationContent "100" @default.
- NCIT_C166700 referenceCount "1" @default.
- NCIT_C166700 hasExactSynonym "OZANIMOD HYDROCHLORIDE" @default.
- NCIT_C166700 hasExactSynonym "Ozanimod Hydrochloride" @default.
- NCIT_C166700 hasExactSynonym "Zeposia" @default.
- NCIT_C166700 inSubset NCIT_C173381 @default.
- NCIT_C166700 inSubset NCIT_C173383 @default.
- NCIT_C166700 inSubset NCIT_C176424 @default.
- NCIT_C166700 inSubset NCIT_C63923 @default.
- NCIT_C166700 type Class @default.
- NCIT_C166700 isDefinedBy ncit.owl @default.
- NCIT_C166700 label "Ozanimod Hydrochloride" @default.
- NCIT_C166700 subClassOf NCIT_C166700 @default.
- NCIT_C166700 subClassOf NCIT_C1908 @default.
- NCIT_C166700 subClassOf NCIT_C1909 @default.
- NCIT_C166700 subClassOf NCIT_C308 @default.
- NCIT_C166700 subClassOf NCIT_C574 @default.