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- NCIT_C166837 IAO_0000115 "An agonist of calcium-sensing receptors (CaSR), with potential use in the treatment of secondary hyperparathyroidism (SHPT). Upon administration, upacicalcet targets and binds to CaSRs expressed on the membranes of cells in the parathyroid glands, which suppresses osteoclast activity and reduces the excessive secretion of parathyroid hormone (PTH). This prevents the excessive PTH-mediated efflux of phosphorus and calcium from bone into the blood and normalizes serum calcium and phosphorus levels. Upacicalcet may decrease the risk of bone fracture, may lower depositions of phosphorus and calcium salts in non-bone tissues, may reduce bone and joint pain and may slow the progression of other diseases related to increased levels of PTH. CaSR controls calcium homeostasis and regulates the release of PTH." @default.
- NCIT_C166837 NCIT_A5 NCIT_C151955 @default.
- NCIT_C166837 NCIT_NHC0 "C166837" @default.
- NCIT_C166837 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C166837 NCIT_P108 "Upacicalcet" @default.
- NCIT_C166837 NCIT_P208 "CL971829" @default.
- NCIT_C166837 NCIT_P210 "1333218-50-0" @default.
- NCIT_C166837 NCIT_P319 "5C1222PBE2" @default.
- NCIT_C166837 NCIT_P322 "FDA" @default.
- NCIT_C166837 normalizedInformationContent "100" @default.
- NCIT_C166837 referenceCount "1" @default.
- NCIT_C166837 hasExactSynonym "PLS 240 Free Base" @default.
- NCIT_C166837 hasExactSynonym "PLS-240 Free Base" @default.
- NCIT_C166837 hasExactSynonym "PLS240 Free Base" @default.
- NCIT_C166837 hasExactSynonym "UPACICALCET" @default.
- NCIT_C166837 hasExactSynonym "Upacicalcet" @default.
- NCIT_C166837 inSubset NCIT_C63923 @default.
- NCIT_C166837 type Class @default.
- NCIT_C166837 isDefinedBy ncit.owl @default.
- NCIT_C166837 label "Upacicalcet" @default.
- NCIT_C166837 subClassOf NCIT_C166837 @default.
- NCIT_C166837 subClassOf NCIT_C1908 @default.
- NCIT_C166837 subClassOf NCIT_C1909 @default.
- NCIT_C166837 subClassOf NCIT_C2136 @default.
- NCIT_C166837 subClassOf NCIT_C78275 @default.