Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C167012> ?p ?o ?g. }
Showing items 1 to 36 of
36
with 100 items per page.
- NCIT_C167012 IAO_0000115 "A recombinant small peptide inhibitor of the terminal complement pathway protein C5 originally derived from a protein in the saliva of the Ornithodoros moubata tick, with potential anti-inflammatory and cytoprotective activities. Upon administration, nomacopan targets and binds to a unique site on the terminal complement protein C5, which blocks C5 cleavage into the pro-inflammatory components C5a and C5b, and prevents the C5b-dependent assembly of the membrane-attack complex (MAC; C5b-9). This prevents MAC-mediated lysis and destruction of red blood cells (RBCs) in paroxysmal nocturnal hemoglobinuria (PNH) and prevents tissue destruction in various other complement-mediated inflammatory and autoimmune diseases. In addition, this C5 inhibitor targets, binds to and inhibits the activity of leukotriene B4 (LTB4), thereby further preventing inflammatory-mediated cell destruction." @default.
- NCIT_C167012 NCIT_NHC0 "C167012" @default.
- NCIT_C167012 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C167012 NCIT_P107 "Nomacopan" @default.
- NCIT_C167012 NCIT_P108 "Nomacopan" @default.
- NCIT_C167012 NCIT_P208 "CL972006" @default.
- NCIT_C167012 NCIT_P210 "875125-19-2" @default.
- NCIT_C167012 NCIT_P319 "79V7Q9VIWQ" @default.
- NCIT_C167012 NCIT_P322 "CTRP" @default.
- NCIT_C167012 NCIT_P322 "FDA" @default.
- NCIT_C167012 NCIT_P399 "795332" @default.
- NCIT_C167012 normalizedInformationContent "100" @default.
- NCIT_C167012 referenceCount "1" @default.
- NCIT_C167012 hasExactSynonym "Complement C5-inhibitor rEV576" @default.
- NCIT_C167012 hasExactSynonym "Coversin" @default.
- NCIT_C167012 hasExactSynonym "NOMACOPAN" @default.
- NCIT_C167012 hasExactSynonym "Nomacopan" @default.
- NCIT_C167012 hasExactSynonym "Recombinant EV576" @default.
- NCIT_C167012 hasExactSynonym "Recombinant OmCI" @default.
- NCIT_C167012 hasExactSynonym "Recombinant Ornithodoros moubata Complement Inhibitor" @default.
- NCIT_C167012 hasExactSynonym "Recombinant Ornithodoros moubata Saliva-derived Small Protein Complement C5 Inhibitor" @default.
- NCIT_C167012 hasExactSynonym "rEV576" @default.
- NCIT_C167012 inSubset NCIT_C116977 @default.
- NCIT_C167012 inSubset NCIT_C116978 @default.
- NCIT_C167012 inSubset NCIT_C176424 @default.
- NCIT_C167012 inSubset NCIT_C63923 @default.
- NCIT_C167012 type Class @default.
- NCIT_C167012 isDefinedBy ncit.owl @default.
- NCIT_C167012 label "Nomacopan" @default.
- NCIT_C167012 subClassOf NCIT_C167012 @default.
- NCIT_C167012 subClassOf NCIT_C1908 @default.
- NCIT_C167012 subClassOf NCIT_C1909 @default.
- NCIT_C167012 subClassOf NCIT_C254 @default.
- NCIT_C167012 subClassOf NCIT_C26170 @default.
- NCIT_C167012 subClassOf NCIT_C308 @default.
- NCIT_C167012 subClassOf NCIT_C574 @default.