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- NCIT_C167120 IAO_0000115 "A recombinant form of asparaginase (Erwinia asparaginase; crisantaspase) derived from the bacterium Erwinia chrysanthemi, genetically engineered to be produced in Pseudomonas fluorescens, with potential antineoplastic activity. Upon administration of recombinant Erwinia asparaginase JZP-458, the recombinant asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia. This depletes cancer cells of asparagine, which blocks protein synthesis and tumor cell proliferation. Asparagine is critical to protein synthesis in cancer cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. JZP-458 can be used as an alternative in patients who are hypersensitive to Escherichia (E.) coli-derived asparaginase products." @default.
- NCIT_C167120 NCIT_NHC0 "C167120" @default.
- NCIT_C167120 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C167120 NCIT_P108 "Recombinant Erwinia asparaginase JZP-458" @default.
- NCIT_C167120 NCIT_P200 "C177280" @default.
- NCIT_C167120 NCIT_P208 "CL972349" @default.
- NCIT_C167120 NCIT_P310 "Retired_Concept" @default.
- NCIT_C167120 NCIT_P98 "Tue Aug 08 16:07:24 EDT 2023 - See 'Asparaginase Erwinia chrysanthemi(C64260)'" @default.
- NCIT_C167120 normalizedInformationContent "100" @default.
- NCIT_C167120 referenceCount "1" @default.
- NCIT_C167120 hasExactSynonym "Recombinant Erwinia asparaginase JZP-458" @default.
- NCIT_C167120 type Class @default.
- NCIT_C167120 isDefinedBy ncit.owl @default.
- NCIT_C167120 label "Recombinant Erwinia asparaginase JZP-458" @default.
- NCIT_C167120 subClassOf NCIT_C167120 @default.
- NCIT_C167120 subClassOf NCIT_C28428 @default.
- NCIT_C167120 subClassOf NCIT_C83485 @default.
- NCIT_C167120 deprecated "true" @default.