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- NCIT_C167124 IAO_0000115 "A radioconjugate composed of a human prostate specific membrane antigen (PSMA)-targeting ligand, Glu-urea-Lys(Ahx) (Glu-NH-CO-NH-Lys(Ahx)) conjugated to both the paramagnetic contrast enhancer gadoxetate and the radioisotope gallium Ga 68, the latter is conjugated via an acyclic radiometal chelator N,N'-bis [2-hydroxy-5-(carboxyethyl)benzyl] ethylenediamine-N,N'-diacetic acid (HBED-CC), with potential use as a tracer for PSMA-expressing tumors during magnetic resonance imaging (MRI) and positron emission tomography (PET). Upon intravenous administration of the gallium Ga 68-labeled PSMA-11-gadoxetate, the Glu-urea-Lys(Ahx) moiety targets and binds to PSMA-expressing tumor cells. PSMA-expressing tumor cells can be detected during PET imaging and MRI. The dual imaging capabilities of this agent may improve both visualization of PSMA-expressing tumor cells and tumor assessment. PSMA, a tumor-associated antigen and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as on some other tumor cell types." @default.
- NCIT_C167124 NCIT_A7 NCIT_C17796 @default.
- NCIT_C167124 NCIT_NHC0 "C167124" @default.
- NCIT_C167124 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C167124 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C167124 NCIT_P107 "Gallium Ga-labeled PSMA-11-Gadoxetate" @default.
- NCIT_C167124 NCIT_P108 "Gallium Ga-labeled PSMA-11-Gadoxetate" @default.
- NCIT_C167124 NCIT_P208 "CL972353" @default.
- NCIT_C167124 NCIT_P322 "CTRP" @default.
- NCIT_C167124 NCIT_P329 "800242" @default.
- NCIT_C167124 NCIT_P330 "800242" @default.
- NCIT_C167124 NCIT_P399 "800242" @default.
- NCIT_C167124 normalizedInformationContent "100" @default.
- NCIT_C167124 referenceCount "1" @default.
- NCIT_C167124 hasExactSynonym "68Ga-PSMA-11-Gadoxetate" @default.
- NCIT_C167124 hasExactSynonym "Gallium Ga-labeled PSMA-11-Gadoxetate" @default.
- NCIT_C167124 inSubset NCIT_C116977 @default.
- NCIT_C167124 inSubset NCIT_C116978 @default.
- NCIT_C167124 inSubset NCIT_C176424 @default.
- NCIT_C167124 type Class @default.
- NCIT_C167124 isDefinedBy ncit.owl @default.
- NCIT_C167124 label "Gallium Ga-labeled PSMA-11-Gadoxetate" @default.
- NCIT_C167124 subClassOf NCIT_C1446 @default.
- NCIT_C167124 subClassOf NCIT_C167124 @default.
- NCIT_C167124 subClassOf NCIT_C1908 @default.
- NCIT_C167124 subClassOf NCIT_C1909 @default.
- NCIT_C167124 subClassOf NCIT_C1966 @default.
- NCIT_C167124 subClassOf NCIT_C2124 @default.
- NCIT_C167124 subClassOf NCIT_C390 @default.
- NCIT_C167124 subClassOf NCIT_C45678 @default.
- NCIT_C167124 subClassOf NCIT_C802 @default.