Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C167210> ?p ?o ?g. }
Showing items 1 to 44 of
44
with 100 items per page.
- NCIT_C167210 IAO_0000115 "An orally bioavailable selective dual inhibitor of fusions and mutations involving the proto-oncogene receptor tyrosine kinase rearranged during transfection (ret) and the src family tyrosine kinases, with potential antineoplastic activity. Upon oral administration, the RET/SRC inhibitor TPX-0046 specifically targets and binds to ret mutants and ret-containing fusion products. This results in an inhibition of cell growth of tumor cells that exhibit increased ret activity. By inhibiting src kinase-mediated signaling and reducing the src-initiated recruitment of multiple receptor tyrosine kinases involved in bypass resistance, TPX-0046 may be able to overcome tumor resistance which may increase its therapeutic effect. Ret overexpression, activating mutations, and fusions result in the upregulation and/or overactivation of ret tyrosine kinase activity in various cancer cell types; dysregulation of ret activity plays a key role in the development and progression of these cancers. Src tyrosine kinases are upregulated in many tumor cells and play important roles in tumor cell proliferation, survival, migration, invasion and angiogenesis. Src upregulation is seen in tumors with acquired resistance to RET inhibitors." @default.
- NCIT_C167210 NCIT_A32 NCIT_C1909 @default.
- NCIT_C167210 NCIT_A7 NCIT_C17389 @default.
- NCIT_C167210 NCIT_A7 NCIT_C18539 @default.
- NCIT_C167210 NCIT_NHC0 "C167210" @default.
- NCIT_C167210 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C167210 NCIT_P107 "RET/SRC Inhibitor TPX-0046" @default.
- NCIT_C167210 NCIT_P108 "RET/SRC Inhibitor TPX-0046" @default.
- NCIT_C167210 NCIT_P208 "CL972435" @default.
- NCIT_C167210 NCIT_P322 "CTRP" @default.
- NCIT_C167210 NCIT_P322 "GDC" @default.
- NCIT_C167210 NCIT_P329 "802260" @default.
- NCIT_C167210 NCIT_P330 "802260" @default.
- NCIT_C167210 NCIT_P375 "RET/SRC Inhibitor TPX-0046" @default.
- NCIT_C167210 NCIT_P399 "802260" @default.
- NCIT_C167210 normalizedInformationContent "100" @default.
- NCIT_C167210 referenceCount "1" @default.
- NCIT_C167210 hasExactSynonym "RET/SRC Inhibitor TPX-0046" @default.
- NCIT_C167210 hasExactSynonym "RET/SRC Tyrosine Kinase Inhibitor TPX-0046" @default.
- NCIT_C167210 hasExactSynonym "TPX 0046" @default.
- NCIT_C167210 hasExactSynonym "TPX-0046" @default.
- NCIT_C167210 hasExactSynonym "TPX0046" @default.
- NCIT_C167210 inSubset NCIT_C116977 @default.
- NCIT_C167210 inSubset NCIT_C116978 @default.
- NCIT_C167210 inSubset NCIT_C128784 @default.
- NCIT_C167210 inSubset NCIT_C157711 @default.
- NCIT_C167210 inSubset NCIT_C157712 @default.
- NCIT_C167210 inSubset NCIT_C176424 @default.
- NCIT_C167210 inSubset NCIT_C177537 @default.
- NCIT_C167210 type Class @default.
- NCIT_C167210 isDefinedBy ncit.owl @default.
- NCIT_C167210 label "RET/SRC Inhibitor TPX-0046" @default.
- NCIT_C167210 subClassOf NCIT_C129824 @default.
- NCIT_C167210 subClassOf NCIT_C129825 @default.
- NCIT_C167210 subClassOf NCIT_C1404 @default.
- NCIT_C167210 subClassOf NCIT_C159438 @default.
- NCIT_C167210 subClassOf NCIT_C163758 @default.
- NCIT_C167210 subClassOf NCIT_C167210 @default.
- NCIT_C167210 subClassOf NCIT_C1908 @default.
- NCIT_C167210 subClassOf NCIT_C1909 @default.
- NCIT_C167210 subClassOf NCIT_C1967 @default.
- NCIT_C167210 subClassOf NCIT_C2189 @default.
- NCIT_C167210 subClassOf NCIT_C274 @default.
- NCIT_C167210 subClassOf NCIT_C471 @default.