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- NCIT_C167220 IAO_0000115 "A preparation of a subset of allogeneic T-lymphocytes that express only gamma chain and delta chain T-cell receptors (TCRs) and that are engineered to express a chimeric antigen receptor (CAR) encoding for human natural-killer group 2, member D receptor protein (NKG2D or KLRK1; natural killer cell activating receptor group 2D), with potential immunomodulating and antineoplastic activities. Upon administration of the NKG2DL-targeting CAR-grafted gamma delta T cells, these cells specifically target and bind to tumor cells expressing NKG2D ligands (NKG2DL). This induces secretion of pro-inflammatory cytokines and results in the lysis of NKG2DL-expressing tumor cells. In addition, these cells target, bind to and kill NKG2DL-expressing tumor-associated endothelial cells in the neovasculature and immunosuppressive cells, such as regulatory T-cells (Tregs) and myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment (TME) that express NKG2D ligands. Gamma/delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. Ligands for NKG2D, such as MHC class I chain-related protein A (MICA), MICB, and members of the UL16-binding proteins (ULBP)/retinoic acid early transcript 1 (RAET1) family, are overexpressed on infected cells and most cancer cell types, but are not expressed on most normal, healthy cells." @default.
- NCIT_C167220 NCIT_NHC0 "C167220" @default.
- NCIT_C167220 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C167220 NCIT_P108 "Allogeneic NKG2DL-targeting CAR-grafted Gamma Delta T Cells" @default.
- NCIT_C167220 NCIT_P208 "CL972443" @default.
- NCIT_C167220 NCIT_P329 "800069" @default.
- NCIT_C167220 NCIT_P330 "800069" @default.
- NCIT_C167220 NCIT_P399 "800069" @default.
- NCIT_C167220 normalizedInformationContent "100" @default.
- NCIT_C167220 referenceCount "1" @default.
- NCIT_C167220 hasExactSynonym "Allogeneic NKG2DL-targeting CAR-gd T-cells" @default.
- NCIT_C167220 hasExactSynonym "Allogeneic NKG2DL-targeting CAR-grafted Gamma Delta T Cells" @default.
- NCIT_C167220 hasExactSynonym "CTM-N2D" @default.
- NCIT_C167220 inSubset NCIT_C128784 @default.
- NCIT_C167220 inSubset NCIT_C176424 @default.
- NCIT_C167220 type Class @default.
- NCIT_C167220 isDefinedBy ncit.owl @default.
- NCIT_C167220 label "Allogeneic NKG2DL-targeting CAR-grafted Gamma Delta T Cells" @default.
- NCIT_C167220 subClassOf NCIT_C129820 @default.
- NCIT_C167220 subClassOf NCIT_C129821 @default.
- NCIT_C167220 subClassOf NCIT_C129826 @default.
- NCIT_C167220 subClassOf NCIT_C137999 @default.
- NCIT_C167220 subClassOf NCIT_C142078 @default.
- NCIT_C167220 subClassOf NCIT_C154231 @default.
- NCIT_C167220 subClassOf NCIT_C167220 @default.
- NCIT_C167220 subClassOf NCIT_C1908 @default.
- NCIT_C167220 subClassOf NCIT_C1909 @default.
- NCIT_C167220 subClassOf NCIT_C1962 @default.
- NCIT_C167220 subClassOf NCIT_C200765 @default.
- NCIT_C167220 subClassOf NCIT_C274 @default.
- NCIT_C167220 subClassOf NCIT_C28676 @default.
- NCIT_C167220 subClassOf NCIT_C307 @default.
- NCIT_C167220 subClassOf NCIT_C308 @default.