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- NCIT_C167239 IAO_0000115 "A fluorescently quenched, cysteine cathepsin-cleavable near infrared (NIR) substrate probe containing the dye indocyanine green (ICG), that may be used for cancer imaging purposes using an NIR imaging system. In 6QC-NIR, the cathepsin-activatable fluorescent probe contains the fluorophore, ICG, linked, via a cathepsin protease cleavable peptide, with a core Cbz-Phe-Lys peptide sequence, to a fluorescent quencher, QC-1. Upon administration of 6QC-NIR, the amide bond of the peptide can be cleaved by cathepsin proteases overexpressed by tumor cells and highly abundant in the tumor microenvironment (TME). Upon proteolysis, the quencher is released, the fluorophore becomes activated and accumulates in the lysosome. Upon clinical NIR imaging, using the da Vinci Si surgical system, tumor cells expressing cathepsin family proteases can be detected which allows for visualization of the tumor." @default.
- NCIT_C167239 NCIT_A7 NCIT_C16389 @default.
- NCIT_C167239 NCIT_NHC0 "C167239" @default.
- NCIT_C167239 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C167239 NCIT_P107 "Cathepsin-cleavable NIR Substrate Probe 6QC-ICG" @default.
- NCIT_C167239 NCIT_P108 "Cathepsin-cleavable NIR Substrate Probe 6QC-ICG" @default.
- NCIT_C167239 NCIT_P208 "CL972463" @default.
- NCIT_C167239 NCIT_P322 "CTRP" @default.
- NCIT_C167239 NCIT_P329 "800448" @default.
- NCIT_C167239 NCIT_P330 "800448" @default.
- NCIT_C167239 NCIT_P399 "800448" @default.
- NCIT_C167239 normalizedInformationContent "100" @default.
- NCIT_C167239 referenceCount "1" @default.
- NCIT_C167239 hasExactSynonym "6QC ICG" @default.
- NCIT_C167239 hasExactSynonym "6QC-ICG" @default.
- NCIT_C167239 hasExactSynonym "6QCICG" @default.
- NCIT_C167239 hasExactSynonym "Cathepsin-cleavable NIR Substrate Probe 6QC-ICG" @default.
- NCIT_C167239 hasExactSynonym "Fluorescently Quenched Protease Substrate Probe 6QC-ICG" @default.
- NCIT_C167239 inSubset NCIT_C116977 @default.
- NCIT_C167239 inSubset NCIT_C116978 @default.
- NCIT_C167239 inSubset NCIT_C176424 @default.
- NCIT_C167239 type Class @default.
- NCIT_C167239 isDefinedBy ncit.owl @default.
- NCIT_C167239 label "Cathepsin-cleavable NIR Substrate Probe 6QC-ICG" @default.
- NCIT_C167239 subClassOf NCIT_C167239 @default.
- NCIT_C167239 subClassOf NCIT_C1908 @default.
- NCIT_C167239 subClassOf NCIT_C1966 @default.
- NCIT_C167239 subClassOf NCIT_C390 @default.
- NCIT_C167239 subClassOf NCIT_C45678 @default.
- NCIT_C167239 subClassOf NCIT_C802 @default.