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- NCIT_C167240 IAO_0000115 "A cysteine cathepsin-cleavable near infrared (NIR) substrate probe, that may be used for cancer imaging purposes using an NIR imaging system. In 6QC-NIR, the cathepsin-activatable fluorescent probe contains the NIR fluorophore, Dylight 780-B1, linked, via a cathepsin protease cleavable peptide, with a core Cbz-Phe-Lys peptide sequence, to a fluorescent quencher, QC-1. Upon administration of 6QC-NIR, the amide bond of the peptide can be cleaved by cathepsins overexpressed by tumor cells and highly abundant in the tumor microenvironment (TME). Upon cleavage, the quencher is released, the fluorophore becomes activated and accumulates in the lysosome. Upon fluorescence imaging, using the da Vinci Si surgical system, tumor cells expressing cathepsin family proteases can be detected which allows for visualization of the tumor." @default.
- NCIT_C167240 NCIT_A7 NCIT_C16389 @default.
- NCIT_C167240 NCIT_NHC0 "C167240" @default.
- NCIT_C167240 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C167240 NCIT_P107 "Cathepsin-cleavable NIR Substrate Probe 6QC-NIR" @default.
- NCIT_C167240 NCIT_P108 "Cathepsin-cleavable NIR Substrate Probe 6QC-NIR" @default.
- NCIT_C167240 NCIT_P208 "CL972462" @default.
- NCIT_C167240 NCIT_P322 "CTRP" @default.
- NCIT_C167240 NCIT_P399 "813329" @default.
- NCIT_C167240 normalizedInformationContent "100" @default.
- NCIT_C167240 referenceCount "1" @default.
- NCIT_C167240 hasExactSynonym "6QC NIR" @default.
- NCIT_C167240 hasExactSynonym "6QC-NIR" @default.
- NCIT_C167240 hasExactSynonym "6QCNIR" @default.
- NCIT_C167240 hasExactSynonym "Cathepsin-cleavable NIR Substrate Probe 6QC-NIR" @default.
- NCIT_C167240 hasExactSynonym "Fluorescently Quenched Protease Substrate Probe 6QC-NIR" @default.
- NCIT_C167240 inSubset NCIT_C116977 @default.
- NCIT_C167240 inSubset NCIT_C116978 @default.
- NCIT_C167240 type Class @default.
- NCIT_C167240 isDefinedBy ncit.owl @default.
- NCIT_C167240 label "Cathepsin-cleavable NIR Substrate Probe 6QC-NIR" @default.
- NCIT_C167240 subClassOf NCIT_C167240 @default.
- NCIT_C167240 subClassOf NCIT_C1908 @default.
- NCIT_C167240 subClassOf NCIT_C1966 @default.
- NCIT_C167240 subClassOf NCIT_C390 @default.
- NCIT_C167240 subClassOf NCIT_C45678 @default.
- NCIT_C167240 subClassOf NCIT_C802 @default.