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- NCIT_C167257 IAO_0000115 "An orally bioavailable, selective, second-generation inhibitor of valosin-containing protein (VCP)/p97, with potential antineoplastic activity. Upon oral administration, p97 inhibitor CB-5339 binds to and inhibits the activity of p97. This prevents ubiquitin-dependent protein degradation and causes cellular accumulation of poly-ubiquitinated proteins. The inhibition of endoplasmic reticulum (ER)-associated protein degradation activates the ER-dependent stress response pathway, and leads to both an induction of apoptosis and the inhibition of cell proliferation in susceptible tumor cells. VCP/p97, a type II AAA+ ATPase, plays a key role in cellular protein homeostasis processes including ER-associated degradation (ERAD), chromatin associated degradation (CAD) and the DNA damage response (DDR). Its overexpression in many tumor cell types is associated with increased tumor cell proliferation and survival." @default.
- NCIT_C167257 NCIT_A32 NCIT_C1909 @default.
- NCIT_C167257 NCIT_A5 NCIT_C167262 @default.
- NCIT_C167257 NCIT_NHC0 "C167257" @default.
- NCIT_C167257 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C167257 NCIT_P107 "p97 Inhibitor CB-5339" @default.
- NCIT_C167257 NCIT_P108 "p97 Inhibitor CB-5339" @default.
- NCIT_C167257 NCIT_P208 "CL972245" @default.
- NCIT_C167257 NCIT_P322 "CTRP" @default.
- NCIT_C167257 NCIT_P322 "GDC" @default.
- NCIT_C167257 NCIT_P329 "800449" @default.
- NCIT_C167257 NCIT_P330 "800449" @default.
- NCIT_C167257 NCIT_P375 "p97 Inhibitor CB-5339" @default.
- NCIT_C167257 NCIT_P399 "800449" @default.
- NCIT_C167257 normalizedInformationContent "100" @default.
- NCIT_C167257 referenceCount "1" @default.
- NCIT_C167257 hasExactSynonym "CB 5339" @default.
- NCIT_C167257 hasExactSynonym "CB-5339" @default.
- NCIT_C167257 hasExactSynonym "CB5339" @default.
- NCIT_C167257 hasExactSynonym "p97 Inhibitor CB-5339" @default.
- NCIT_C167257 inSubset NCIT_C116977 @default.
- NCIT_C167257 inSubset NCIT_C116978 @default.
- NCIT_C167257 inSubset NCIT_C128784 @default.
- NCIT_C167257 inSubset NCIT_C157711 @default.
- NCIT_C167257 inSubset NCIT_C157712 @default.
- NCIT_C167257 inSubset NCIT_C176424 @default.
- NCIT_C167257 inSubset NCIT_C177537 @default.
- NCIT_C167257 type Class @default.
- NCIT_C167257 isDefinedBy ncit.owl @default.
- NCIT_C167257 label "p97 Inhibitor CB-5339" @default.
- NCIT_C167257 subClassOf NCIT_C167257 @default.
- NCIT_C167257 subClassOf NCIT_C1908 @default.
- NCIT_C167257 subClassOf NCIT_C1909 @default.
- NCIT_C167257 subClassOf NCIT_C471 @default.