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- NCIT_C167262 IAO_0000115 "The tosylate salt of CB-5339, an orally bioavailable, selective, second-generation inhibitor of valosin-containing protein (VCP)/p97, with potential antineoplastic activity. Upon oral administration, p97 inhibitor CB-5339 binds to and inhibits the activity of p97. This prevents ubiquitin-dependent protein degradation and causes cellular accumulation of poly-ubiquitinated proteins. The inhibition of endoplasmic reticulum (ER)-associated protein degradation activates the ER-dependent stress response pathway, and leads to both an induction of apoptosis and the inhibition of cell proliferation in susceptible tumor cells. VCP/p97, a type II AAA+ ATPase, plays a key role in cellular protein homeostasis processes including endoplasmic reticulum associated degradation (ERAD), chromatin associated degradation (CAD) and the DNA damage response (DDR). Its overexpression in many tumor cell types is associated with increased tumor cell proliferation and survival." @default.
- NCIT_C167262 NCIT_A32 NCIT_C1909 @default.
- NCIT_C167262 NCIT_A6 NCIT_C167257 @default.
- NCIT_C167262 NCIT_NHC0 "C167262" @default.
- NCIT_C167262 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C167262 NCIT_P107 "p97 Inhibitor CB-5339 Tosylate" @default.
- NCIT_C167262 NCIT_P108 "p97 Inhibitor CB-5339 Tosylate" @default.
- NCIT_C167262 NCIT_P208 "CL972249" @default.
- NCIT_C167262 NCIT_P322 "CTRP" @default.
- NCIT_C167262 NCIT_P322 "GDC" @default.
- NCIT_C167262 NCIT_P329 "800450" @default.
- NCIT_C167262 NCIT_P330 "800450" @default.
- NCIT_C167262 NCIT_P375 "p97 Inhibitor CB-5339 Tosylate" @default.
- NCIT_C167262 NCIT_P399 "800450" @default.
- NCIT_C167262 normalizedInformationContent "100" @default.
- NCIT_C167262 referenceCount "1" @default.
- NCIT_C167262 hasExactSynonym "CB 5339 Tosylate" @default.
- NCIT_C167262 hasExactSynonym "CB-5339 Tosylate" @default.
- NCIT_C167262 hasExactSynonym "CB5339 Tosylate" @default.
- NCIT_C167262 hasExactSynonym "p97 Inhibitor CB-5339 Tosylate" @default.
- NCIT_C167262 inSubset NCIT_C116977 @default.
- NCIT_C167262 inSubset NCIT_C116978 @default.
- NCIT_C167262 inSubset NCIT_C128784 @default.
- NCIT_C167262 inSubset NCIT_C157711 @default.
- NCIT_C167262 inSubset NCIT_C157712 @default.
- NCIT_C167262 inSubset NCIT_C176424 @default.
- NCIT_C167262 inSubset NCIT_C177537 @default.
- NCIT_C167262 type Class @default.
- NCIT_C167262 isDefinedBy ncit.owl @default.
- NCIT_C167262 label "p97 Inhibitor CB-5339 Tosylate" @default.
- NCIT_C167262 subClassOf NCIT_C167262 @default.
- NCIT_C167262 subClassOf NCIT_C1908 @default.
- NCIT_C167262 subClassOf NCIT_C1909 @default.
- NCIT_C167262 subClassOf NCIT_C471 @default.