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- NCIT_C167271 IAO_0000115 "An antagonist of both the C-X-C chemokine receptor type 4 (CXCR4) and E-selectin (CD62E), with potential antineoplastic activity. Upon administration, CXCR4/E-selectin antagonist GMI-1359 binds to both CXCR4 and E-selectin expressed on endothelial cells. The binding to CXCR4 prevents the binding of stromal-cell derived factor-1 (SDF-1; CXCL12) to CXCR4 and inhibits CXCR4 activation, which may result in decreased proliferation and migration of CXCR4-expressing tumor cells. The binding to E-selectin expressed on endothelial cells prevents their interaction with E-selectin ligand-expressing cancer cells. This may prevent tumor cell activation, migration and metastasis. CXCR4, a chemokine receptor belonging to the G protein-coupled receptor (GPCR) family, plays an important role in chemotaxis and angiogenesis, and is upregulated in several tumor cell types. E-selectin is a cell adhesion molecule involved in cell rolling, signaling and chemotaxis. Its overexpression has been associated with tumor angiogenesis and metastasis in several cancers." @default.
- NCIT_C167271 NCIT_A32 NCIT_C1909 @default.
- NCIT_C167271 NCIT_A7 NCIT_C17491 @default.
- NCIT_C167271 NCIT_A7 NCIT_C17789 @default.
- NCIT_C167271 NCIT_NHC0 "C167271" @default.
- NCIT_C167271 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C167271 NCIT_P107 "CXCR4/E-selectin Antagonist GMI-1359" @default.
- NCIT_C167271 NCIT_P108 "CXCR4/E-selectin Antagonist GMI-1359" @default.
- NCIT_C167271 NCIT_P208 "CL972258" @default.
- NCIT_C167271 NCIT_P322 "CTRP" @default.
- NCIT_C167271 NCIT_P322 "GDC" @default.
- NCIT_C167271 NCIT_P329 "802777" @default.
- NCIT_C167271 NCIT_P330 "802777" @default.
- NCIT_C167271 NCIT_P375 "CXCR4/E-selectin Antagonist GMI-1359" @default.
- NCIT_C167271 NCIT_P399 "802777" @default.
- NCIT_C167271 normalizedInformationContent "100" @default.
- NCIT_C167271 referenceCount "1" @default.
- NCIT_C167271 hasExactSynonym "CXCR4/E-selectin Antagonist GMI-1359" @default.
- NCIT_C167271 hasExactSynonym "GMI 1359" @default.
- NCIT_C167271 hasExactSynonym "GMI-1359" @default.
- NCIT_C167271 hasExactSynonym "GMI1359" @default.
- NCIT_C167271 inSubset NCIT_C116977 @default.
- NCIT_C167271 inSubset NCIT_C116978 @default.
- NCIT_C167271 inSubset NCIT_C128784 @default.
- NCIT_C167271 inSubset NCIT_C157711 @default.
- NCIT_C167271 inSubset NCIT_C157712 @default.
- NCIT_C167271 inSubset NCIT_C176424 @default.
- NCIT_C167271 inSubset NCIT_C177537 @default.
- NCIT_C167271 type Class @default.
- NCIT_C167271 isDefinedBy ncit.owl @default.
- NCIT_C167271 label "CXCR4/E-selectin Antagonist GMI-1359" @default.
- NCIT_C167271 subClassOf NCIT_C107589 @default.
- NCIT_C167271 subClassOf NCIT_C129824 @default.
- NCIT_C167271 subClassOf NCIT_C167271 @default.
- NCIT_C167271 subClassOf NCIT_C1908 @default.
- NCIT_C167271 subClassOf NCIT_C1909 @default.
- NCIT_C167271 subClassOf NCIT_C2189 @default.
- NCIT_C167271 subClassOf NCIT_C274 @default.
- NCIT_C167271 subClassOf NCIT_C308 @default.
- NCIT_C167271 subClassOf NCIT_C63817 @default.