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- NCIT_C167326 IAO_0000115 "A donor graft derived from allogeneic filgrastim (granulocyte-colony stimulating factor; G-CSF)-mobilized peripheral blood cells (MPBC) that have been incubated with the recombinant human Fas ligand (FasL) APO010 ex vivo, and that can potentially be used for immune reconstitution purposes. The incubation of the hematopoietic stem cell graft with the apoptotic mediator Fas ligand (FasL) selectively induces apoptosis of mature T-cells which express high levels of Fas receptor, such as T stem cell memory (TSCM), T central memory (TCM), and T effector memory (TEM) cells and the pro-inflammatory T-helper cells (Th) Th1 and Th17 subsets while sparing CD34-positive stem and progenitor cells. Upon washing and further ex vivo preparations, and upon allogeneic hematopoietic stem cell transplantation (HSCT) with the FasL-treated allogeneic MPBCs, these cells provide hematopoietic cell recovery, preserve the graft-versus-leukemia (GvL) effects, and may prevent graft-versus-host disease (GvHD)." @default.
- NCIT_C167326 NCIT_A32 NCIT_C1909 @default.
- NCIT_C167326 NCIT_NHC0 "C167326" @default.
- NCIT_C167326 NCIT_P106 "Cell" @default.
- NCIT_C167326 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C167326 NCIT_P107 "Fas Ligand-treated Allogeneic Mobilized Peripheral Blood Cells" @default.
- NCIT_C167326 NCIT_P108 "Fas Ligand-treated Allogeneic Mobilized Peripheral Blood Cells" @default.
- NCIT_C167326 NCIT_P208 "CL972303" @default.
- NCIT_C167326 NCIT_P322 "CTRP" @default.
- NCIT_C167326 NCIT_P322 "GDC" @default.
- NCIT_C167326 NCIT_P375 "Fas Ligand-treated Allogeneic Mobilized Peripheral Blood Cells" @default.
- NCIT_C167326 normalizedInformationContent "100" @default.
- NCIT_C167326 referenceCount "1" @default.
- NCIT_C167326 hasExactSynonym "Allogeneic Apograft Stem Cells" @default.
- NCIT_C167326 hasExactSynonym "Apograft-incubated Mobilized Peripheral Blood Stem Cells" @default.
- NCIT_C167326 hasExactSynonym "Apograft-treated Allogeneic MPBCs" @default.
- NCIT_C167326 hasExactSynonym "Apograft-treated MPBCs" @default.
- NCIT_C167326 hasExactSynonym "Fas Ligand-treated Allogeneic Mobilized Peripheral Blood Cell Product" @default.
- NCIT_C167326 hasExactSynonym "Fas Ligand-treated Allogeneic Mobilized Peripheral Blood Cells" @default.
- NCIT_C167326 hasExactSynonym "FasL-treated Mobilized Peripheral Blood Cells" @default.
- NCIT_C167326 inSubset NCIT_C116977 @default.
- NCIT_C167326 inSubset NCIT_C116978 @default.
- NCIT_C167326 inSubset NCIT_C157711 @default.
- NCIT_C167326 inSubset NCIT_C157712 @default.
- NCIT_C167326 inSubset NCIT_C177537 @default.
- NCIT_C167326 type Class @default.
- NCIT_C167326 isDefinedBy ncit.owl @default.
- NCIT_C167326 label "Fas Ligand-treated Allogeneic Mobilized Peripheral Blood Cells" @default.
- NCIT_C167326 subClassOf NCIT_C142078 @default.
- NCIT_C167326 subClassOf NCIT_C167326 @default.
- NCIT_C167326 subClassOf NCIT_C1908 @default.
- NCIT_C167326 subClassOf NCIT_C1909 @default.
- NCIT_C167326 subClassOf NCIT_C201557 @default.
- NCIT_C167326 subClassOf NCIT_C307 @default.
- NCIT_C167326 subClassOf NCIT_C308 @default.