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- NCIT_C167334 IAO_0000115 "A pegylated conjugate of SN-38 (7-ethyl-10-hydroxy-camptothecin), a biologically active metabolite of the prodrug irinotecan, with potential antineoplastic activity. Upon administration, the proprietary linker slowly releases SN-38 from the pegylated SN-38 conjugate PLX038. SN-38 binds to and inhibits topoisomerase I by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA replication, and apoptosis. Compared with irinotecan, this formulation allows higher accumulation in solid tumors due to its nanoparticle size and long half-life." @default.
- NCIT_C167334 NCIT_A32 NCIT_C1909 @default.
- NCIT_C167334 NCIT_A7 NCIT_C16516 @default.
- NCIT_C167334 NCIT_NHC0 "C167334" @default.
- NCIT_C167334 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C167334 NCIT_P107 "Pegylated SN-38 Conjugate PLX038" @default.
- NCIT_C167334 NCIT_P108 "Pegylated SN-38 Conjugate PLX038" @default.
- NCIT_C167334 NCIT_P208 "CL972311" @default.
- NCIT_C167334 NCIT_P322 "CTRP" @default.
- NCIT_C167334 NCIT_P322 "GDC" @default.
- NCIT_C167334 NCIT_P329 "800470" @default.
- NCIT_C167334 NCIT_P330 "800470" @default.
- NCIT_C167334 NCIT_P375 "Pegylated SN-38 Conjugate PLX038" @default.
- NCIT_C167334 NCIT_P399 "800470" @default.
- NCIT_C167334 normalizedInformationContent "100" @default.
- NCIT_C167334 referenceCount "1" @default.
- NCIT_C167334 hasExactSynonym "PLX 038" @default.
- NCIT_C167334 hasExactSynonym "PLX-038" @default.
- NCIT_C167334 hasExactSynonym "PLX038" @default.
- NCIT_C167334 hasExactSynonym "Pegylated SN-38 Conjugate PLX038" @default.
- NCIT_C167334 hasExactSynonym "Pegylated SN-38 PLX038" @default.
- NCIT_C167334 inSubset NCIT_C116977 @default.
- NCIT_C167334 inSubset NCIT_C116978 @default.
- NCIT_C167334 inSubset NCIT_C128784 @default.
- NCIT_C167334 inSubset NCIT_C157711 @default.
- NCIT_C167334 inSubset NCIT_C157712 @default.
- NCIT_C167334 inSubset NCIT_C176424 @default.
- NCIT_C167334 inSubset NCIT_C177537 @default.
- NCIT_C167334 type Class @default.
- NCIT_C167334 isDefinedBy ncit.owl @default.
- NCIT_C167334 label "Pegylated SN-38 Conjugate PLX038" @default.
- NCIT_C167334 subClassOf NCIT_C129824 @default.
- NCIT_C167334 subClassOf NCIT_C129825 @default.
- NCIT_C167334 subClassOf NCIT_C167334 @default.
- NCIT_C167334 subClassOf NCIT_C1748 @default.
- NCIT_C167334 subClassOf NCIT_C1904 @default.
- NCIT_C167334 subClassOf NCIT_C1908 @default.
- NCIT_C167334 subClassOf NCIT_C1909 @default.
- NCIT_C167334 subClassOf NCIT_C2189 @default.
- NCIT_C167334 subClassOf NCIT_C274 @default.
- NCIT_C167334 subClassOf NCIT_C471 @default.