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- NCIT_C167337 IAO_0000115 "An immunotherapeutic combination agent composed of antigen receptor complex T cells (ARC-T cells) which contain a proprietary binding domain specific for a universal TAG instead of a single chain variable fragment (scFv) binding domain, and a tumor-targeting antigen protein, soluble protein antigen-receptor X-linker (sparX) protein, containing a TAG moiety fused to two B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) binding domains, with potential antineoplastic activities. Upon administration of the anti-BCMA sparX protein plus BCMA-directed ARC T-cells CART-ddBCMA, the sparX protein, with its two BCMA binding domains, specifically targets and binds to two BCMA expressed on tumor cells. In turn, the ARC-T cells, with their anti-TAG domain, target and bind to the TAG domain on the sparX protein. This directly links the ARC-T cells to the BCMA-expressing tumor cells, through the ARC-T cell- sparX -tumor cell complex formation, thereby causing direct tumor cell killing. BCMA, a tumor-associated antigen (TAA), is found on the surfaces of plasma cells and is overexpressed on a variety of tumor cell types. Compared to anti-BCMA CAR-T cells, CART-ddBCMA, containing ARC-T cells that are re-programmed in vivo by the TAG sparX protein, shows enhanced efficiency and an improved safety profile. As ARC-T activity is dependent on the sparX dose administered, the rate of tumor cell killing, and related toxicities are also dependent on the sparX dose administered." @default.
- NCIT_C167337 NCIT_A32 NCIT_C1909 @default.
- NCIT_C167337 NCIT_A7 NCIT_C97848 @default.
- NCIT_C167337 NCIT_NHC0 "C167337" @default.
- NCIT_C167337 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C167337 NCIT_P107 "Anti-BCMA SparX Protein Plus BCMA-directed Anti-TAAG ARC T-cells CART-ddBCMA" @default.
- NCIT_C167337 NCIT_P108 "Anti-BCMA SparX Protein Plus BCMA-directed Anti-TAAG ARC T-cells CART-ddBCMA" @default.
- NCIT_C167337 NCIT_P208 "CL972316" @default.
- NCIT_C167337 NCIT_P322 "CTRP" @default.
- NCIT_C167337 NCIT_P322 "GDC" @default.
- NCIT_C167337 NCIT_P329 "800471" @default.
- NCIT_C167337 NCIT_P330 "800471" @default.
- NCIT_C167337 NCIT_P375 "Anti-BCMA SparX Protein Plus BCMA-directed Anti-TAAG ARC T-cells CART-ddBCMA" @default.
- NCIT_C167337 NCIT_P399 "800471" @default.
- NCIT_C167337 normalizedInformationContent "100" @default.
- NCIT_C167337 referenceCount "1" @default.
- NCIT_C167337 hasExactSynonym "ARC-T Plus Anti-BCMA SparX" @default.
- NCIT_C167337 hasExactSynonym "Anti-BCMA SparX Protein Plus BCMA-directed Anti-TAAG ARC T-cells CART-ddBCMA" @default.
- NCIT_C167337 hasExactSynonym "Anti-TAG ARC-T Cells Directed by BCMA Bi-valent/TAG SparX Protein" @default.
- NCIT_C167337 hasExactSynonym "Immunotherapeutic Combination Agent SparX Protein Plus CART-ddBCMA" @default.
- NCIT_C167337 hasExactSynonym "TAG-containing SparX /Bivalent BCMA-targeted ARC-T Cells" @default.
- NCIT_C167337 inSubset NCIT_C116977 @default.
- NCIT_C167337 inSubset NCIT_C116978 @default.
- NCIT_C167337 inSubset NCIT_C128784 @default.
- NCIT_C167337 inSubset NCIT_C157711 @default.
- NCIT_C167337 inSubset NCIT_C157712 @default.
- NCIT_C167337 inSubset NCIT_C176424 @default.
- NCIT_C167337 inSubset NCIT_C177537 @default.
- NCIT_C167337 type Class @default.
- NCIT_C167337 isDefinedBy ncit.owl @default.
- NCIT_C167337 label "Anti-BCMA SparX Protein Plus BCMA-directed Anti-TAAG ARC T-cells CART-ddBCMA" @default.
- NCIT_C167337 subClassOf NCIT_C129821 @default.
- NCIT_C167337 subClassOf NCIT_C167337 @default.
- NCIT_C167337 subClassOf NCIT_C1908 @default.
- NCIT_C167337 subClassOf NCIT_C1909 @default.
- NCIT_C167337 subClassOf NCIT_C274 @default.
- NCIT_C167337 subClassOf NCIT_C307 @default.
- NCIT_C167337 subClassOf NCIT_C308 @default.
- NCIT_C167337 subClassOf NCIT_C717 @default.