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- NCIT_C168589 IAO_0000115 "The tosylate form of valemetostat, an orally available selective inhibitor of the histone lysine methyltransferases enhancer of zeste homolog 1 (EZH1) and 2 (EZH2), with potential antineoplastic activity. Upon oral administration, valemetostat selectively inhibits the activity of both wild-type and mutated forms of EZH1 and EZH2. Inhibition of EZH1/2 specifically prevents the methylation of lysine 27 on histone H3 (H3K27). This decrease in histone methylation alters gene expression patterns associated with cancer pathways, enhances transcription of certain target genes, and results in decreased proliferation of EZH1/2-expressing cancer cells. EZH1/2, histone lysine methyltransferase (HMT) class enzymes and catalytic subunits of the polycomb repressive complex 2 (PRC2), are overexpressed or mutated in a variety of cancer cells and play key roles in tumor cell proliferation, progression, stem cell self-renewal and migration." @default.
- NCIT_C168589 NCIT_A7 NCIT_C30175 @default.
- NCIT_C168589 NCIT_NHC0 "C168589" @default.
- NCIT_C168589 NCIT_P106 "Organic Chemical" @default.
- NCIT_C168589 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C168589 NCIT_P107 "Valemetostat Tosylate" @default.
- NCIT_C168589 NCIT_P108 "Valemetostat Tosylate" @default.
- NCIT_C168589 NCIT_P208 "CL972910" @default.
- NCIT_C168589 NCIT_P210 "1809336-93-3" @default.
- NCIT_C168589 NCIT_P319 "6N79I7X5II" @default.
- NCIT_C168589 NCIT_P322 "CTRP" @default.
- NCIT_C168589 NCIT_P322 "FDA" @default.
- NCIT_C168589 NCIT_P329 "780797" @default.
- NCIT_C168589 NCIT_P330 "780797" @default.
- NCIT_C168589 NCIT_P399 "780797" @default.
- NCIT_C168589 normalizedInformationContent "100" @default.
- NCIT_C168589 referenceCount "1" @default.
- NCIT_C168589 hasExactSynonym "1,3-Benzodioxole-5-carboxamide, 7-Chloro-N-((1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl)-2-(trans-4-(dimethylamino)cyclohexyl)-2,4-dimethyl-, (2R)-, Compd. with 4-Methylbenzenesulfonate (1:1)" @default.
- NCIT_C168589 hasExactSynonym "DS 3201b" @default.
- NCIT_C168589 hasExactSynonym "DS-3201 Tosylate" @default.
- NCIT_C168589 hasExactSynonym "DS-3201b" @default.
- NCIT_C168589 hasExactSynonym "VALEMETOSTAT TOSYLATE" @default.
- NCIT_C168589 hasExactSynonym "Valemetostat Tosylate" @default.
- NCIT_C168589 inSubset NCIT_C116977 @default.
- NCIT_C168589 inSubset NCIT_C116978 @default.
- NCIT_C168589 inSubset NCIT_C176424 @default.
- NCIT_C168589 inSubset NCIT_C63923 @default.
- NCIT_C168589 type Class @default.
- NCIT_C168589 isDefinedBy ncit.owl @default.
- NCIT_C168589 label "Valemetostat Tosylate" @default.
- NCIT_C168589 subClassOf NCIT_C129824 @default.
- NCIT_C168589 subClassOf NCIT_C129825 @default.
- NCIT_C168589 subClassOf NCIT_C156804 @default.
- NCIT_C168589 subClassOf NCIT_C168589 @default.
- NCIT_C168589 subClassOf NCIT_C1908 @default.
- NCIT_C168589 subClassOf NCIT_C1909 @default.
- NCIT_C168589 subClassOf NCIT_C2189 @default.
- NCIT_C168589 subClassOf NCIT_C274 @default.
- NCIT_C168589 subClassOf NCIT_C471 @default.