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- NCIT_C168601 IAO_0000115 "An orally bioavailable inhibitor of the nuclear enzymes poly (ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, senaparib selectively binds to PARP 1 and 2 and prevents PARP-mediated DNA repair of single-strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks and promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks." @default.
- NCIT_C168601 NCIT_A32 NCIT_C1909 @default.
- NCIT_C168601 NCIT_NHC0 "C168601" @default.
- NCIT_C168601 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C168601 NCIT_P108 "Senaparib" @default.
- NCIT_C168601 NCIT_P208 "CL972916" @default.
- NCIT_C168601 NCIT_P210 "1401682-78-7" @default.
- NCIT_C168601 NCIT_P319 "MNZ4OP95CF" @default.
- NCIT_C168601 NCIT_P322 "FDA" @default.
- NCIT_C168601 NCIT_P322 "GDC" @default.
- NCIT_C168601 NCIT_P329 "800374" @default.
- NCIT_C168601 NCIT_P330 "800374" @default.
- NCIT_C168601 NCIT_P375 "PARP 1/2 Inhibitor IMP4297" @default.
- NCIT_C168601 NCIT_P399 "800374" @default.
- NCIT_C168601 NCIT_R146 NCIT_C104101 @default.
- NCIT_C168601 NCIT_R146 NCIT_C16554 @default.
- NCIT_C168601 NCIT_R146 NCIT_C17021 @default.
- NCIT_C168601 NCIT_R146 NCIT_C17210 @default.
- NCIT_C168601 NCIT_R146 NCIT_C17434 @default.
- NCIT_C168601 NCIT_R146 NCIT_C20027 @default.
- NCIT_C168601 NCIT_R146 NCIT_C21170 @default.
- NCIT_C168601 NCIT_R146 NCIT_C26548 @default.
- NCIT_C168601 NCIT_R146 NCIT_C48215 @default.
- NCIT_C168601 normalizedInformationContent "100" @default.
- NCIT_C168601 referenceCount "1" @default.
- NCIT_C168601 hasExactSynonym "IMP 4297" @default.
- NCIT_C168601 hasExactSynonym "IMP-4297" @default.
- NCIT_C168601 hasExactSynonym "IMP4297" @default.
- NCIT_C168601 hasExactSynonym "PARP 1/2 Inhibitor IMP4297" @default.
- NCIT_C168601 hasExactSynonym "SENAPARIB" @default.
- NCIT_C168601 hasExactSynonym "Senaparib" @default.
- NCIT_C168601 inSubset NCIT_C128784 @default.
- NCIT_C168601 inSubset NCIT_C157711 @default.
- NCIT_C168601 inSubset NCIT_C157712 @default.
- NCIT_C168601 inSubset NCIT_C176424 @default.
- NCIT_C168601 inSubset NCIT_C177537 @default.
- NCIT_C168601 inSubset NCIT_C63923 @default.
- NCIT_C168601 type Class @default.
- NCIT_C168601 isDefinedBy ncit.owl @default.
- NCIT_C168601 label "Senaparib" @default.
- NCIT_C168601 subClassOf NCIT_C163758 @default.
- NCIT_C168601 subClassOf NCIT_C168601 @default.
- NCIT_C168601 subClassOf NCIT_C1908 @default.
- NCIT_C168601 subClassOf NCIT_C1909 @default.
- NCIT_C168601 subClassOf NCIT_C274 @default.
- NCIT_C168601 subClassOf NCIT_C471 @default.
- NCIT_C168601 subClassOf NCIT_C62554 @default.