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- NCIT_C168687 IAO_0000115 "The anhydrous form of enol-oxaloacetate, a small molecule blood glutamate scavenger, that can be used to lower glutamate plasma levels, and has potential neuroprotective activity. Upon administration, enol-oxaloacetate targets and binds to glutamate in the bloodstream. This lowers glutamate plasma levels and lowers the free glutamate available to be picked up by cells, such as tumor brain cells, thereby preventing glutamate metabolism and glutamate-mediated signaling. This prevents the proliferation of rapidly growing cells, such as brain tumor cells. And by lowering glutamate plasma levels, a molecular imbalance is formed and glutamate is excreted across the blood-brain barrier, resulting in lower free brain glutamate. This may help protect the brain from excitotoxicity in conditions where there is a surge of glutamate production, such as traumatic brain injury, thereby protecting neuronal cells. Glutamate, a non-essential amino acid and the major excitatory neurotransmitter in the central nervous system (CNS), provides energy and generates building blocks for the production of macromolecules, which are needed for cellular growth and survival." @default.
- NCIT_C168687 NCIT_A32 NCIT_C1909 @default.
- NCIT_C168687 NCIT_NHC0 "C168687" @default.
- NCIT_C168687 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C168687 NCIT_P107 "Anhydrous Enol-oxaloacetate" @default.
- NCIT_C168687 NCIT_P108 "Anhydrous Enol-oxaloacetate" @default.
- NCIT_C168687 NCIT_P208 "CL1378618" @default.
- NCIT_C168687 NCIT_P210 "328-42-7" @default.
- NCIT_C168687 NCIT_P319 "2F399MM81J" @default.
- NCIT_C168687 NCIT_P322 "CTRP" @default.
- NCIT_C168687 NCIT_P322 "FDA" @default.
- NCIT_C168687 NCIT_P322 "GDC" @default.
- NCIT_C168687 NCIT_P329 "800694" @default.
- NCIT_C168687 NCIT_P330 "800694" @default.
- NCIT_C168687 NCIT_P375 "Anhydrous Enol-oxaloacetate" @default.
- NCIT_C168687 NCIT_P399 "800694" @default.
- NCIT_C168687 normalizedInformationContent "100" @default.
- NCIT_C168687 referenceCount "1" @default.
- NCIT_C168687 hasExactSynonym "AEO" @default.
- NCIT_C168687 hasExactSynonym "Anhydrous Enol-oxaloacetate" @default.
- NCIT_C168687 hasExactSynonym "OXALOACETIC ACID" @default.
- NCIT_C168687 inSubset NCIT_C116977 @default.
- NCIT_C168687 inSubset NCIT_C116978 @default.
- NCIT_C168687 inSubset NCIT_C128784 @default.
- NCIT_C168687 inSubset NCIT_C157711 @default.
- NCIT_C168687 inSubset NCIT_C157712 @default.
- NCIT_C168687 inSubset NCIT_C176424 @default.
- NCIT_C168687 inSubset NCIT_C177537 @default.
- NCIT_C168687 inSubset NCIT_C63923 @default.
- NCIT_C168687 type Class @default.
- NCIT_C168687 isDefinedBy ncit.owl @default.
- NCIT_C168687 label "Anhydrous Enol-oxaloacetate" @default.
- NCIT_C168687 subClassOf NCIT_C1509 @default.
- NCIT_C168687 subClassOf NCIT_C168687 @default.
- NCIT_C168687 subClassOf NCIT_C177430 @default.
- NCIT_C168687 subClassOf NCIT_C1908 @default.
- NCIT_C168687 subClassOf NCIT_C1909 @default.
- NCIT_C168687 subClassOf NCIT_C26170 @default.
- NCIT_C168687 subClassOf NCIT_C274 @default.