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- NCIT_C168776 IAO_0000115 "A topical cream containing the alkaloid caffeine in a lipoderm base, with potential anti-inflammatory, anti-fibrotic, protective and antioxidant activities. Upon topical application of the caffeine-based cream to the affected area(s), the caffeine inhibits phosphodiesterase (PDE) activity, thereby stimulating the degradation of fats during lipolysis. Caffeine also reduces the levels of certain pro-inflammatory cytokines, such as the profibrotic cytokine transforming growth factor beta (TGFb,) and matrix metalloproteinases (MMPs), thereby preventing inflammation and protecting against collagen degradation. In addition, caffeine protects cells from oxidative stress. This may help protect skin, reduce skin-related complications and improve skin appearance." @default.
- NCIT_C168776 NCIT_NHC0 "C168776" @default.
- NCIT_C168776 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C168776 NCIT_P107 "Caffeine-based Cream" @default.
- NCIT_C168776 NCIT_P108 "Caffeine-based Cream" @default.
- NCIT_C168776 NCIT_P208 "CL1378683" @default.
- NCIT_C168776 NCIT_P322 "CTRP" @default.
- NCIT_C168776 NCIT_P399 "810804" @default.
- NCIT_C168776 normalizedInformationContent "100" @default.
- NCIT_C168776 referenceCount "1" @default.
- NCIT_C168776 hasExactSynonym "Caffeine Based Cream" @default.
- NCIT_C168776 hasExactSynonym "Caffeine-Lipoderm Cream" @default.
- NCIT_C168776 hasExactSynonym "Caffeine-based Cream" @default.
- NCIT_C168776 hasExactSynonym "Caffeine-containing Lipoderm Cream" @default.
- NCIT_C168776 inSubset NCIT_C116977 @default.
- NCIT_C168776 inSubset NCIT_C116978 @default.
- NCIT_C168776 inSubset NCIT_C176424 @default.
- NCIT_C168776 type Class @default.
- NCIT_C168776 isDefinedBy ncit.owl @default.
- NCIT_C168776 label "Caffeine-based Cream" @default.
- NCIT_C168776 subClassOf NCIT_C168776 @default.
- NCIT_C168776 subClassOf NCIT_C1908 @default.
- NCIT_C168776 subClassOf NCIT_C1909 @default.
- NCIT_C168776 subClassOf NCIT_C29629 @default.
- NCIT_C168776 subClassOf NCIT_C29639 @default.