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- NCIT_C1689 IAO_0000115 "A cyclic depsipeptide isolated from the marine tunicate Aplidium albicans. Plitidepsin displays a broad spectrum of antitumor activities, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation. This agent also inhibits elongation factor 1-a, thereby interfering with protein synthesis, and induces G1 arrest and G2 blockade, thereby inhibiting tumor cell growth." @default.
- NCIT_C1689 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1689 NCIT_NHC0 "C1689" @default.
- NCIT_C1689 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C1689 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1689 NCIT_P107 "Plitidepsin" @default.
- NCIT_C1689 NCIT_P108 "Plitidepsin" @default.
- NCIT_C1689 NCIT_P175 "638719" @default.
- NCIT_C1689 NCIT_P207 "C0388638" @default.
- NCIT_C1689 NCIT_P210 "137219-37-5" @default.
- NCIT_C1689 NCIT_P319 "Y76ID234HW" @default.
- NCIT_C1689 NCIT_P322 "CTRP" @default.
- NCIT_C1689 NCIT_P322 "FDA" @default.
- NCIT_C1689 NCIT_P322 "GDC" @default.
- NCIT_C1689 NCIT_P325 "A substance that is being studied in the treatment of cancer. It is obtained from a marine organism." @default.
- NCIT_C1689 NCIT_P329 "460052" @default.
- NCIT_C1689 NCIT_P330 "460052" @default.
- NCIT_C1689 NCIT_P366 "Aplidine" @default.
- NCIT_C1689 NCIT_P375 "Plitidepsin" @default.
- NCIT_C1689 NCIT_P399 "460052" @default.
- NCIT_C1689 normalizedInformationContent "100" @default.
- NCIT_C1689 referenceCount "1" @default.
- NCIT_C1689 hasExactSynonym "APLD" @default.
- NCIT_C1689 hasExactSynonym "Aplidin" @default.
- NCIT_C1689 hasExactSynonym "Aplidine" @default.
- NCIT_C1689 hasExactSynonym "DDB" @default.
- NCIT_C1689 hasExactSynonym "Dehydrodemnin B" @default.
- NCIT_C1689 hasExactSynonym "Dehydrodidemnin B" @default.
- NCIT_C1689 hasExactSynonym "N-[1-(1,2-Dioxopropyl)-L-prolyl]didemnin A" @default.
- NCIT_C1689 hasExactSynonym "PLITIDEPSIN" @default.
- NCIT_C1689 hasExactSynonym "Plitidepsin" @default.
- NCIT_C1689 hasExactSynonym "aplidine" @default.
- NCIT_C1689 inSubset NCIT_C116977 @default.
- NCIT_C1689 inSubset NCIT_C116978 @default.
- NCIT_C1689 inSubset NCIT_C128784 @default.
- NCIT_C1689 inSubset NCIT_C157711 @default.
- NCIT_C1689 inSubset NCIT_C157712 @default.
- NCIT_C1689 inSubset NCIT_C173381 @default.
- NCIT_C1689 inSubset NCIT_C173383 @default.
- NCIT_C1689 inSubset NCIT_C176424 @default.
- NCIT_C1689 inSubset NCIT_C177537 @default.
- NCIT_C1689 inSubset NCIT_C63923 @default.
- NCIT_C1689 type Class @default.
- NCIT_C1689 isDefinedBy ncit.owl @default.
- NCIT_C1689 label "Plitidepsin" @default.
- NCIT_C1689 subClassOf NCIT_C1689 @default.
- NCIT_C1689 subClassOf NCIT_C186664 @default.
- NCIT_C1689 subClassOf NCIT_C1908 @default.
- NCIT_C1689 subClassOf NCIT_C1909 @default.
- NCIT_C1689 subClassOf NCIT_C1976 @default.
- NCIT_C1689 subClassOf NCIT_C259 @default.
- NCIT_C1689 subClassOf NCIT_C274 @default.
- NCIT_C1689 subClassOf NCIT_C784 @default.