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- NCIT_C169756 IAO_0000115 "The maleate salt form of abivertinib, an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic activity. Upon oral administration, abivertinib covalently binds to and inhibits the activity of mutant forms of EGFR, including the drug-resistant T790M EGFR mutant, which prevents signaling mediated by mutant forms of EGFR. This may both induce cell death and inhibit tumor growth in EGFR-mutated tumor cells. EGFR, a receptor tyrosine kinase that is mutated in a variety of cancers, plays a key role in tumor cell proliferation and tumor vascularization. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced when compared to non-selective EGFR inhibitors, which also inhibit wild-type EGFR." @default.
- NCIT_C169756 NCIT_A6 NCIT_C147125 @default.
- NCIT_C169756 NCIT_NHC0 "C169756" @default.
- NCIT_C169756 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C169756 NCIT_P108 "Abivertinib Maleate" @default.
- NCIT_C169756 NCIT_P208 "CL1382258" @default.
- NCIT_C169756 NCIT_P210 "1822357-78-7" @default.
- NCIT_C169756 NCIT_P319 "Y50131AMFJ" @default.
- NCIT_C169756 NCIT_P322 "FDA" @default.
- NCIT_C169756 normalizedInformationContent "100" @default.
- NCIT_C169756 referenceCount "1" @default.
- NCIT_C169756 hasExactSynonym "ABIVERTINIB MALEATE" @default.
- NCIT_C169756 hasExactSynonym "Abivertinib Maleate" @default.
- NCIT_C169756 inSubset NCIT_C173381 @default.
- NCIT_C169756 inSubset NCIT_C173383 @default.
- NCIT_C169756 inSubset NCIT_C63923 @default.
- NCIT_C169756 type Class @default.
- NCIT_C169756 isDefinedBy ncit.owl @default.
- NCIT_C169756 label "Abivertinib Maleate" @default.
- NCIT_C169756 subClassOf NCIT_C129824 @default.
- NCIT_C169756 subClassOf NCIT_C129825 @default.
- NCIT_C169756 subClassOf NCIT_C1404 @default.
- NCIT_C169756 subClassOf NCIT_C163758 @default.
- NCIT_C169756 subClassOf NCIT_C163952 @default.
- NCIT_C169756 subClassOf NCIT_C169756 @default.
- NCIT_C169756 subClassOf NCIT_C1908 @default.
- NCIT_C169756 subClassOf NCIT_C1909 @default.
- NCIT_C169756 subClassOf NCIT_C1967 @default.
- NCIT_C169756 subClassOf NCIT_C2167 @default.
- NCIT_C169756 subClassOf NCIT_C2189 @default.
- NCIT_C169756 subClassOf NCIT_C274 @default.
- NCIT_C169756 subClassOf NCIT_C471 @default.