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- NCIT_C169827 IAO_0000115 "The hydrochloride salt form of cariprazine, an orally bioavailable partial agonist of the dopamine D2 and D3 receptors, a partial agonist of the serotonin 1A (5-HT1A) receptor, and an antagonist of the serotonin 2A (5-HT2A) and 2B (5-HT2B) receptors, with antipsychotic activity. Although its exact mechanism of action in schizophrenia is unknown, it has been proposed that cariprazine's antipsychotic activity is mediated through a combination of agonist and antagonist activities at various dopamine and serotonin receptors, particularly through its partial agonist activity at central dopamine D2 and 5-HT1A receptors, and its antagonist activity at 5-HT2A receptor." @default.
- NCIT_C169827 NCIT_NHC0 "C169827" @default.
- NCIT_C169827 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C169827 NCIT_P108 "Cariprazine Hydrochloride" @default.
- NCIT_C169827 NCIT_P208 "CL1382167" @default.
- NCIT_C169827 NCIT_P210 "1083076-69-0" @default.
- NCIT_C169827 NCIT_P319 "KQD7C255YG" @default.
- NCIT_C169827 NCIT_P322 "FDA" @default.
- NCIT_C169827 normalizedInformationContent "100" @default.
- NCIT_C169827 referenceCount "1" @default.
- NCIT_C169827 hasExactSynonym "CARIPRAZINE HYDROCHLORIDE" @default.
- NCIT_C169827 hasExactSynonym "Cariprazine Hydrochloride" @default.
- NCIT_C169827 hasExactSynonym "RGH-188 Hydrochloride" @default.
- NCIT_C169827 hasExactSynonym "Vraylar" @default.
- NCIT_C169827 inSubset NCIT_C63923 @default.
- NCIT_C169827 type Class @default.
- NCIT_C169827 isDefinedBy ncit.owl @default.
- NCIT_C169827 label "Cariprazine Hydrochloride" @default.
- NCIT_C169827 subClassOf NCIT_C169827 @default.
- NCIT_C169827 subClassOf NCIT_C1908 @default.
- NCIT_C169827 subClassOf NCIT_C1909 @default.
- NCIT_C169827 subClassOf NCIT_C29710 @default.
- NCIT_C169827 subClassOf NCIT_C78272 @default.