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- NCIT_C1699 IAO_0000115 "A synthetic imidazole bisphosphonate analog of pyrophosphate with anti-bone-resorption activity. A third-generation bisphosphonate, zoledronic acid binds to hydroxyapatite crystals in the bone matrix, slowing their dissolution and inhibiting the formation and aggregation of these crystals. This agent also inhibits farnesyl pyrophosphate synthase, an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids, donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which are important in the process of osteoclast turnover. Decreased bone turnover and stabilization of the bone matrix contribute to the analgesic effect of zoledronic acid with respect to painful osteoblastic lesions. The agent also reduces serum calcium concentrations associated with hypercalcemia." @default.
- NCIT_C1699 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1699 NCIT_A5 NCIT_C66703 @default.
- NCIT_C1699 NCIT_A5 NCIT_C80325 @default.
- NCIT_C1699 NCIT_NHC0 "C1699" @default.
- NCIT_C1699 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1699 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1699 NCIT_P107 "Zoledronic Acid" @default.
- NCIT_C1699 NCIT_P108 "Zoledronic Acid" @default.
- NCIT_C1699 NCIT_P175 "721517" @default.
- NCIT_C1699 NCIT_P207 "C0257685" @default.
- NCIT_C1699 NCIT_P210 "165800-06-6" @default.
- NCIT_C1699 NCIT_P302 "Hypercalcemia of malignancy; Multiple myeloma and metastatic bone lesions from solid tumors; Paget's disease" @default.
- NCIT_C1699 NCIT_P319 "6XC1PAD3KF" @default.
- NCIT_C1699 NCIT_P322 "CTRP" @default.
- NCIT_C1699 NCIT_P322 "FDA" @default.
- NCIT_C1699 NCIT_P322 "GDC" @default.
- NCIT_C1699 NCIT_P322 "PCDC" @default.
- NCIT_C1699 NCIT_P325 "A drug used to treat patients with hypercalcemia (high blood levels of calcium) caused by cancer. It is also used together with other drugs to treat multiple myeloma and to prevent bone fractures and reduce bone pain in people who have cancer that has spread to the bone. It is a type of bisphosphonate." @default.
- NCIT_C1699 NCIT_P329 "42507" @default.
- NCIT_C1699 NCIT_P330 "42507" @default.
- NCIT_C1699 NCIT_P350 "C5H10N2O7P2.H2O" @default.
- NCIT_C1699 NCIT_P366 "Zoledronate" @default.
- NCIT_C1699 NCIT_P375 "Zoledronic Acid" @default.
- NCIT_C1699 NCIT_P399 "42507" @default.
- NCIT_C1699 NCIT_R124 NCIT_C17710 @default.
- NCIT_C1699 NCIT_R124 NCIT_C17828 @default.
- NCIT_C1699 NCIT_R124 NCIT_C19986 @default.
- NCIT_C1699 NCIT_R124 NCIT_C40551 @default.
- NCIT_C1699 NCIT_R125 NCIT_C17828 @default.
- NCIT_C1699 NCIT_R125 NCIT_C20150 @default.
- NCIT_C1699 NCIT_R125 NCIT_C20480 @default.
- NCIT_C1699 NCIT_R125 NCIT_C40715 @default.
- NCIT_C1699 NCIT_R125 NCIT_C41515 @default.
- NCIT_C1699 NCIT_R125 NCIT_C51037 @default.
- NCIT_C1699 normalizedInformationContent "86.239998175184226" @default.
- NCIT_C1699 referenceCount "8" @default.
- NCIT_C1699 hasExactSynonym "Aclasta" @default.
- NCIT_C1699 hasExactSynonym "CGP 42446" @default.
- NCIT_C1699 hasExactSynonym "CGP42446A" @default.
- NCIT_C1699 hasExactSynonym "NDC-Zoledronate" @default.
- NCIT_C1699 hasExactSynonym "Reclast" @default.
- NCIT_C1699 hasExactSynonym "ZOL 446" @default.
- NCIT_C1699 hasExactSynonym "ZOLEDRONIC ACID" @default.
- NCIT_C1699 hasExactSynonym "Zoledronate" @default.
- NCIT_C1699 hasExactSynonym "Zoledronic Acid" @default.
- NCIT_C1699 hasExactSynonym "Zometa" @default.
- NCIT_C1699 hasExactSynonym "[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic Acid" @default.
- NCIT_C1699 hasExactSynonym "zoledronic acid" @default.
- NCIT_C1699 inSubset NCIT_C116977 @default.
- NCIT_C1699 inSubset NCIT_C116978 @default.
- NCIT_C1699 inSubset NCIT_C128784 @default.
- NCIT_C1699 inSubset NCIT_C157711 @default.
- NCIT_C1699 inSubset NCIT_C157712 @default.
- NCIT_C1699 inSubset NCIT_C176424 @default.
- NCIT_C1699 inSubset NCIT_C177537 @default.
- NCIT_C1699 inSubset NCIT_C179478 @default.
- NCIT_C1699 inSubset NCIT_C179531 @default.
- NCIT_C1699 inSubset NCIT_C63923 @default.
- NCIT_C1699 type Class @default.
- NCIT_C1699 isDefinedBy ncit.owl @default.
- NCIT_C1699 label "Zoledronic Acid" @default.
- NCIT_C1699 subClassOf B185b6f148f56c0515611afdeea27de5b @default.
- NCIT_C1699 subClassOf B54fed808240e5d0b3245acf96a88e84f @default.
- NCIT_C1699 subClassOf B978a68d81f6552282b18fb10444c7b33 @default.
- NCIT_C1699 subClassOf Bac7ef5480f53f860c1e1e4d22e3b8fe2 @default.
- NCIT_C1699 subClassOf NCIT_C1699 @default.
- NCIT_C1699 subClassOf NCIT_C1908 @default.
- NCIT_C1699 subClassOf NCIT_C1909 @default.
- NCIT_C1699 subClassOf NCIT_C1913 @default.
- NCIT_C1699 subClassOf NCIT_C2136 @default.
- NCIT_C1699 subClassOf NCIT_C443 @default.
- NCIT_C1699 subClassOf NCIT_C67439 @default.
- NCIT_C1699 subClassOf NCIT_C718 @default.
- NCIT_C1699 subClassOf NCIT_C78275 @default.
- NCIT_C1699 subClassOf NCIT_C78281 @default.