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- NCIT_C169931 IAO_0000115 "A homogenous hexameric agonist fusion protein composed of the extracellular domain (ECD) of the T-cell costimulatory receptor human glucocorticoid-induced tumor necrosis factor receptor (tumor necrosis factor superfamily, member 18; TNFRSF18; GITR) ligand (GITRL) and an immunoglobulin (Ig) G1 Fc domain, with potential immunomodulating and antineoplastic activities. Upon administration, efgivanermin alfa binds to and activates GITR found on multiple types of T-cells, thereby inducing both the activation and proliferation of tumor antigen-specific T effector cells. This abrogates the suppression of T effector cells which is induced by inappropriately activated T regulatory cells (Tregs), suppresses Tregs and decreases Treg tumor infiltration, and activates the immune system to help eradicate tumor cells. GITR, a member of the TNF receptor superfamily, is expressed on the surface of multiple types of immune cells, including Tregs, effector T-cells, B-cells, dendritic cells (DCs) and natural killer (NK) cells." @default.
- NCIT_C169931 NCIT_A32 NCIT_C1909 @default.
- NCIT_C169931 NCIT_A7 NCIT_C105568 @default.
- NCIT_C169931 NCIT_NHC0 "C169931" @default.
- NCIT_C169931 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C169931 NCIT_P107 "Efgivanermin Alfa" @default.
- NCIT_C169931 NCIT_P108 "Efgivanermin Alfa" @default.
- NCIT_C169931 NCIT_P208 "CL1382432" @default.
- NCIT_C169931 NCIT_P210 "1807864-13-6" @default.
- NCIT_C169931 NCIT_P319 "Y2R45V0JU8" @default.
- NCIT_C169931 NCIT_P322 "CTRP" @default.
- NCIT_C169931 NCIT_P322 "FDA" @default.
- NCIT_C169931 NCIT_P322 "GDC" @default.
- NCIT_C169931 NCIT_P375 "GITR Agonist MEDI1873" @default.
- NCIT_C169931 NCIT_P399 "776837" @default.
- NCIT_C169931 normalizedInformationContent "100" @default.
- NCIT_C169931 referenceCount "1" @default.
- NCIT_C169931 hasExactSynonym "EFGIVANERMIN ALFA" @default.
- NCIT_C169931 hasExactSynonym "Efgivanermin Alfa" @default.
- NCIT_C169931 hasExactSynonym "GITR Agonist MEDI1873" @default.
- NCIT_C169931 hasExactSynonym "GITR Stimulant MEDI1873" @default.
- NCIT_C169931 hasExactSynonym "MEDI 1873" @default.
- NCIT_C169931 hasExactSynonym "MEDI1873" @default.
- NCIT_C169931 hasExactSynonym "TNFRSF18 Agonist MEDI1873" @default.
- NCIT_C169931 hasExactSynonym "TNFRSF18 Protein Stimulant MEDI1873" @default.
- NCIT_C169931 inSubset NCIT_C116977 @default.
- NCIT_C169931 inSubset NCIT_C116978 @default.
- NCIT_C169931 inSubset NCIT_C128784 @default.
- NCIT_C169931 inSubset NCIT_C157711 @default.
- NCIT_C169931 inSubset NCIT_C157712 @default.
- NCIT_C169931 inSubset NCIT_C176424 @default.
- NCIT_C169931 inSubset NCIT_C177537 @default.
- NCIT_C169931 inSubset NCIT_C63923 @default.
- NCIT_C169931 type Class @default.
- NCIT_C169931 isDefinedBy ncit.owl @default.
- NCIT_C169931 label "Efgivanermin Alfa" @default.
- NCIT_C169931 subClassOf NCIT_C129820 @default.
- NCIT_C169931 subClassOf NCIT_C141144 @default.
- NCIT_C169931 subClassOf NCIT_C1512 @default.
- NCIT_C169931 subClassOf NCIT_C169931 @default.
- NCIT_C169931 subClassOf NCIT_C1908 @default.
- NCIT_C169931 subClassOf NCIT_C1909 @default.
- NCIT_C169931 subClassOf NCIT_C201119 @default.
- NCIT_C169931 subClassOf NCIT_C274 @default.
- NCIT_C169931 subClassOf NCIT_C307 @default.
- NCIT_C169931 subClassOf NCIT_C308 @default.