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- NCIT_C170255 IAO_0000115 "An orally bioavailable progesterone receptor (PR) antagonist, with potential antineoplastic activity. Upon oral administration, onapristone binds to the PR and inhibits both PR activation and the associated expression of PR-responsive genes. This may inhibit PR-mediated proliferative effects in cancer cells overexpressing PR. In addition, onapristone may downregulate cancer stem cell mobilization and block immune evasion. PR is expressed on certain cancer cell types and plays a key role in tumor cell proliferation and survival." @default.
- NCIT_C170255 NCIT_A7 NCIT_C17075 @default.
- NCIT_C170255 NCIT_NHC0 "C170255" @default.
- NCIT_C170255 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C170255 NCIT_P107 "Onapristone" @default.
- NCIT_C170255 NCIT_P108 "Onapristone" @default.
- NCIT_C170255 NCIT_P208 "CL1382731" @default.
- NCIT_C170255 NCIT_P210 "96346-61-1" @default.
- NCIT_C170255 NCIT_P319 "H6H7G23O3N" @default.
- NCIT_C170255 NCIT_P322 "CTRP" @default.
- NCIT_C170255 NCIT_P322 "FDA" @default.
- NCIT_C170255 NCIT_P399 "812047" @default.
- NCIT_C170255 normalizedInformationContent "100" @default.
- NCIT_C170255 referenceCount "1" @default.
- NCIT_C170255 hasExactSynonym "ONAPRISTONE" @default.
- NCIT_C170255 hasExactSynonym "Onapristone" @default.
- NCIT_C170255 inSubset NCIT_C116977 @default.
- NCIT_C170255 inSubset NCIT_C116978 @default.
- NCIT_C170255 inSubset NCIT_C176424 @default.
- NCIT_C170255 inSubset NCIT_C63923 @default.
- NCIT_C170255 type Class @default.
- NCIT_C170255 isDefinedBy ncit.owl @default.
- NCIT_C170255 label "Onapristone" @default.
- NCIT_C170255 subClassOf NCIT_C147908 @default.
- NCIT_C170255 subClassOf NCIT_C170255 @default.
- NCIT_C170255 subClassOf NCIT_C1891 @default.
- NCIT_C170255 subClassOf NCIT_C1908 @default.
- NCIT_C170255 subClassOf NCIT_C1909 @default.
- NCIT_C170255 subClassOf NCIT_C547 @default.