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- NCIT_C170279 IAO_0000115 "An orally bioavailable sphingosine-1-phosphate (S1P) receptors 1 (S1PR1, S1P1) and 5 (S1PR5, S1P5) modulator, with potential anti-inflammatory and immunomodulating activities. Upon oral administration, ozanimod selectively targets and binds to S1PR1 on lymphocytes and induces S1PR1 internalization and degradation. This results in the sequestration of lymphocytes in lymph nodes. By preventing egress of lymphocytes, ozanimod reduces both the amount of circulating peripheral lymphocytes and the infiltration of lymphocytes into target tissues. This prevents a lymphocyte-mediated immune response and may reduce inflammation. S1PR1, a G-protein coupled receptor, plays a key role in lymphocyte migration from lymphoid tissues. Modulation of S1PR5 by ozanimod may be neuroprotective." @default.
- NCIT_C170279 NCIT_A5 NCIT_C166700 @default.
- NCIT_C170279 NCIT_NHC0 "C170279" @default.
- NCIT_C170279 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C170279 NCIT_P108 "Ozanimod" @default.
- NCIT_C170279 NCIT_P208 "CL1382523" @default.
- NCIT_C170279 NCIT_P210 "1306760-87-1" @default.
- NCIT_C170279 NCIT_P319 "Z80293URPV" @default.
- NCIT_C170279 NCIT_P322 "FDA" @default.
- NCIT_C170279 normalizedInformationContent "100" @default.
- NCIT_C170279 referenceCount "1" @default.
- NCIT_C170279 hasExactSynonym "OZANIMOD" @default.
- NCIT_C170279 hasExactSynonym "Ozanimod" @default.
- NCIT_C170279 hasExactSynonym "RPC 1063" @default.
- NCIT_C170279 hasExactSynonym "RPC-1063" @default.
- NCIT_C170279 hasExactSynonym "RPC1063" @default.
- NCIT_C170279 inSubset NCIT_C173381 @default.
- NCIT_C170279 inSubset NCIT_C173383 @default.
- NCIT_C170279 inSubset NCIT_C63923 @default.
- NCIT_C170279 type Class @default.
- NCIT_C170279 isDefinedBy ncit.owl @default.
- NCIT_C170279 label "Ozanimod" @default.
- NCIT_C170279 subClassOf NCIT_C170279 @default.
- NCIT_C170279 subClassOf NCIT_C1908 @default.
- NCIT_C170279 subClassOf NCIT_C1909 @default.
- NCIT_C170279 subClassOf NCIT_C308 @default.
- NCIT_C170279 subClassOf NCIT_C574 @default.