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- NCIT_C170314 IAO_0000115 "The hydrochloride salt form of pexidartinib, a small-molecule receptor tyrosine kinase (RTK) inhibitor of proto-oncogene receptor tyrosine kinase (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), with antineoplastic activity. Upon oral administration, pexidartinib targets, binds to and inhibits phosphorylation of KIT, CSF1R and FLT3 harboring an internal tandem duplication (ITD) mutation. This results in the inhibition of tumor cell proliferation. FLT3, CSF1R and FLT3 are overexpressed or mutated in many cancer cell types and play major roles in tumor cell proliferation and metastasis." @default.
- NCIT_C170314 NCIT_A6 NCIT_C88303 @default.
- NCIT_C170314 NCIT_A7 NCIT_C17328 @default.
- NCIT_C170314 NCIT_A7 NCIT_C17392 @default.
- NCIT_C170314 NCIT_A7 NCIT_C26202 @default.
- NCIT_C170314 NCIT_NHC0 "C170314" @default.
- NCIT_C170314 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C170314 NCIT_P107 "Pexidartinib Hydrochloride" @default.
- NCIT_C170314 NCIT_P108 "Pexidartinib Hydrochloride" @default.
- NCIT_C170314 NCIT_P208 "CL1382556" @default.
- NCIT_C170314 NCIT_P210 "2040295-03-0" @default.
- NCIT_C170314 NCIT_P319 "YS6WAI3XN7" @default.
- NCIT_C170314 NCIT_P322 "CTRP" @default.
- NCIT_C170314 NCIT_P322 "FDA" @default.
- NCIT_C170314 NCIT_P329 "659167" @default.
- NCIT_C170314 NCIT_P330 "659167" @default.
- NCIT_C170314 NCIT_P399 "659167" @default.
- NCIT_C170314 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C170314 referenceCount "2" @default.
- NCIT_C170314 hasExactSynonym "(5-(5-Chloro-1H-pyrrolo(2,3-b)pyridin-3-ylmethyl)-pyridin-2-yl)-(6-trifluoromethyl-pyridin-3-ylmethyl)-amine Hydrochloride Salt" @default.
- NCIT_C170314 hasExactSynonym "5[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-{[6-(trifluoromethyl)pyridin-3yl]methyl}pyridin-2-amine Monohydrochloride" @default.
- NCIT_C170314 hasExactSynonym "FP-113" @default.
- NCIT_C170314 hasExactSynonym "PEXIDARTINIB HYDROCHLORIDE" @default.
- NCIT_C170314 hasExactSynonym "PLX3397 Hydrochloride" @default.
- NCIT_C170314 hasExactSynonym "Pexidartinib Hydrochloride" @default.
- NCIT_C170314 hasExactSynonym "Pexidartinib Monohydrochloride" @default.
- NCIT_C170314 hasExactSynonym "Turalio" @default.
- NCIT_C170314 inSubset NCIT_C116977 @default.
- NCIT_C170314 inSubset NCIT_C116978 @default.
- NCIT_C170314 inSubset NCIT_C176424 @default.
- NCIT_C170314 inSubset NCIT_C63923 @default.
- NCIT_C170314 type Class @default.
- NCIT_C170314 isDefinedBy ncit.owl @default.
- NCIT_C170314 label "Pexidartinib Hydrochloride" @default.
- NCIT_C170314 subClassOf NCIT_C129824 @default.
- NCIT_C170314 subClassOf NCIT_C129825 @default.
- NCIT_C170314 subClassOf NCIT_C1404 @default.
- NCIT_C170314 subClassOf NCIT_C170314 @default.
- NCIT_C170314 subClassOf NCIT_C1908 @default.
- NCIT_C170314 subClassOf NCIT_C1909 @default.
- NCIT_C170314 subClassOf NCIT_C1967 @default.
- NCIT_C170314 subClassOf NCIT_C2189 @default.
- NCIT_C170314 subClassOf NCIT_C274 @default.
- NCIT_C170314 subClassOf NCIT_C471 @default.