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- NCIT_C170744 IAO_0000115 "An inhibitor of the fibroblast growth factor receptor (FGFR) type 2 (FGFR2), with potential antineoplastic and anti-angiogenic activities. Upon administration, alofanib targets, allosterically binds to the extracellular domain of FGFR2 and inhibits the activity of FGFR2, which may result in the inhibition of basic FGF (bFGF)/FGFR2-related signal transduction pathways. This inhibits FGF-induced endothelial cell proliferation and migration, and inhibits the proliferation of FGFR2-overexpressing tumor cells. FGFR2, a receptor tyrosine kinase upregulated in many tumor cell types, plays a key role in cellular proliferation, migration and survival." @default.
- NCIT_C170744 NCIT_A32 NCIT_C1909 @default.
- NCIT_C170744 NCIT_A7 NCIT_C17297 @default.
- NCIT_C170744 NCIT_NHC0 "C170744" @default.
- NCIT_C170744 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C170744 NCIT_P108 "Alofanib" @default.
- NCIT_C170744 NCIT_P208 "CL1383158" @default.
- NCIT_C170744 NCIT_P210 "1612888-66-0" @default.
- NCIT_C170744 NCIT_P319 "LQX7RFK8MZ" @default.
- NCIT_C170744 NCIT_P322 "FDA" @default.
- NCIT_C170744 NCIT_P322 "GDC" @default.
- NCIT_C170744 NCIT_P329 "800699" @default.
- NCIT_C170744 NCIT_P330 "800699" @default.
- NCIT_C170744 NCIT_P375 "Alofanib" @default.
- NCIT_C170744 NCIT_P399 "800699" @default.
- NCIT_C170744 normalizedInformationContent "100" @default.
- NCIT_C170744 referenceCount "1" @default.
- NCIT_C170744 hasExactSynonym "ALOFANIB" @default.
- NCIT_C170744 hasExactSynonym "Alofanib" @default.
- NCIT_C170744 hasExactSynonym "Benzoic Acid, 3-(((4-Methyl-2-nitro-5-(3-pyridinyl)phenyl)amino)sulfonyl)-" @default.
- NCIT_C170744 hasExactSynonym "ES000835" @default.
- NCIT_C170744 hasExactSynonym "RPT 835" @default.
- NCIT_C170744 hasExactSynonym "RPT-835" @default.
- NCIT_C170744 hasExactSynonym "RPT835" @default.
- NCIT_C170744 inSubset NCIT_C128784 @default.
- NCIT_C170744 inSubset NCIT_C157711 @default.
- NCIT_C170744 inSubset NCIT_C157712 @default.
- NCIT_C170744 inSubset NCIT_C176424 @default.
- NCIT_C170744 inSubset NCIT_C177537 @default.
- NCIT_C170744 inSubset NCIT_C63923 @default.
- NCIT_C170744 type Class @default.
- NCIT_C170744 isDefinedBy ncit.owl @default.
- NCIT_C170744 label "Alofanib" @default.
- NCIT_C170744 subClassOf NCIT_C129824 @default.
- NCIT_C170744 subClassOf NCIT_C129825 @default.
- NCIT_C170744 subClassOf NCIT_C1404 @default.
- NCIT_C170744 subClassOf NCIT_C155727 @default.
- NCIT_C170744 subClassOf NCIT_C163758 @default.
- NCIT_C170744 subClassOf NCIT_C164035 @default.
- NCIT_C170744 subClassOf NCIT_C170744 @default.
- NCIT_C170744 subClassOf NCIT_C1908 @default.
- NCIT_C170744 subClassOf NCIT_C1909 @default.
- NCIT_C170744 subClassOf NCIT_C1967 @default.
- NCIT_C170744 subClassOf NCIT_C2189 @default.
- NCIT_C170744 subClassOf NCIT_C274 @default.
- NCIT_C170744 subClassOf NCIT_C471 @default.