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- NCIT_C170747 IAO_0000115 "A preparation of autologous T-lymphocytes that have been transduced with a vector expressing a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) specific for the epitome cluster E3 in the extracellular domain (ECD) of the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) that is fused to the co-stimulatory domain of 4-1BB (CD137) and the T-cell receptor signaling domain of CD3zeta (CD3z), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-BCMA-CAR-4-1BB-CD3zeta-expressing T-cells C-CAR088 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in the survival of B-lymphocytes and plasma cells. BCMA is found on the surfaces of B-cells and is overexpressed on malignant plasma cells." @default.
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- NCIT_C170747 NCIT_P108 "Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-expressing T-cells C-CAR088" @default.
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- NCIT_C170747 hasExactSynonym "Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-expressing T-cells C-CAR088" @default.
- NCIT_C170747 hasExactSynonym "Autologous BCMA-directed CAR-T Cells C-CAR088" @default.
- NCIT_C170747 hasExactSynonym "C-CAR 088" @default.
- NCIT_C170747 hasExactSynonym "C-CAR-088" @default.
- NCIT_C170747 hasExactSynonym "C-CAR088" @default.
- NCIT_C170747 inSubset NCIT_C128784 @default.
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- NCIT_C170747 type Class @default.
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- NCIT_C170747 label "Autologous Anti-BCMA-CAR-4-1BB-CD3zeta-expressing T-cells C-CAR088" @default.
- NCIT_C170747 subClassOf NCIT_C129820 @default.
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- NCIT_C170747 subClassOf NCIT_C307 @default.
- NCIT_C170747 subClassOf NCIT_C308 @default.