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- NCIT_C170763 IAO_0000115 "An orally bioavailable inhibitor of numerous tyrosine kinases (TKs) including fibroblast growth factor receptor (FGFR), vascular endothelial growth factor receptor type 2 (VEGFR2; KDR), and colony stimulating factor 1 receptor (CSF1R; CSF-1R), with potential antiangiogenic and antineoplastic activities. Upon oral administration, simmitinib binds to and inhibits the activities of these TKs, thereby preventing both the activation of downstream signaling pathways and the proliferation of tumor cells overexpressing these TKs. FGFR, VEGFR2, and CSF1R are upregulated in a variety of cancer cell types and play key roles in tumor cell proliferation, angiogenesis, and metastasis." @default.
- NCIT_C170763 NCIT_A32 NCIT_C1909 @default.
- NCIT_C170763 NCIT_NHC0 "C170763" @default.
- NCIT_C170763 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C170763 NCIT_P108 "Simmitinib" @default.
- NCIT_C170763 NCIT_P208 "CL1383173" @default.
- NCIT_C170763 NCIT_P322 "GDC" @default.
- NCIT_C170763 NCIT_P329 "800788" @default.
- NCIT_C170763 NCIT_P330 "800788" @default.
- NCIT_C170763 NCIT_P375 "Simmitinib" @default.
- NCIT_C170763 NCIT_P399 "800788" @default.
- NCIT_C170763 normalizedInformationContent "100" @default.
- NCIT_C170763 referenceCount "1" @default.
- NCIT_C170763 hasExactSynonym "SOMCL-15-290" @default.
- NCIT_C170763 hasExactSynonym "Simmitinib" @default.
- NCIT_C170763 inSubset NCIT_C128784 @default.
- NCIT_C170763 inSubset NCIT_C157711 @default.
- NCIT_C170763 inSubset NCIT_C157712 @default.
- NCIT_C170763 inSubset NCIT_C176424 @default.
- NCIT_C170763 inSubset NCIT_C177537 @default.
- NCIT_C170763 type Class @default.
- NCIT_C170763 isDefinedBy ncit.owl @default.
- NCIT_C170763 label "Simmitinib" @default.
- NCIT_C170763 subClassOf NCIT_C129824 @default.
- NCIT_C170763 subClassOf NCIT_C129825 @default.
- NCIT_C170763 subClassOf NCIT_C1404 @default.
- NCIT_C170763 subClassOf NCIT_C155727 @default.
- NCIT_C170763 subClassOf NCIT_C163758 @default.
- NCIT_C170763 subClassOf NCIT_C163953 @default.
- NCIT_C170763 subClassOf NCIT_C164035 @default.
- NCIT_C170763 subClassOf NCIT_C170763 @default.
- NCIT_C170763 subClassOf NCIT_C1742 @default.
- NCIT_C170763 subClassOf NCIT_C1908 @default.
- NCIT_C170763 subClassOf NCIT_C1909 @default.
- NCIT_C170763 subClassOf NCIT_C1967 @default.
- NCIT_C170763 subClassOf NCIT_C2189 @default.
- NCIT_C170763 subClassOf NCIT_C274 @default.
- NCIT_C170763 subClassOf NCIT_C471 @default.
- NCIT_C170763 subClassOf NCIT_C93259 @default.