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- NCIT_C170894 IAO_0000115 "A designed ankyrin repeat proteins (DARPin)-based agent targeting the tumor-associated protein fibroblast activation protein (FAP) and the T-cell co-stimulatory immune receptor 4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential immunomodulating and antineoplastic activities. Upon administration, the FAP/4-1BB-targeting DARPin MP0310 targets and binds to both FAP, localized on tumor stromal cells, and 4-1BB, expressed on a variety of leukocyte subsets including activated T-lymphocytes and natural killer (NK) cells. The simultaneous binding of FAP and 4-1BB results in local clustering of FAP-expressing tumor stromal cells and 4-1BB-expressing T-cells, and local immune cell activation through the promotion of T-cell activation, cytokine release and T-cell-mediated anti-tumor immune responses. 4-1BB, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity. FAP is abundantly expressed by cancer associated fibroblasts in the majority of solid tumors. Compared to antibodies, DARPins are small in size, have favorable pharmacokinetics and allow for both high affinity binding and efficacy." @default.
- NCIT_C170894 NCIT_A32 NCIT_C1909 @default.
- NCIT_C170894 NCIT_A7 NCIT_C105113 @default.
- NCIT_C170894 NCIT_A7 NCIT_C17799 @default.
- NCIT_C170894 NCIT_NHC0 "C170894" @default.
- NCIT_C170894 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C170894 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C170894 NCIT_P108 "FAP/4-1BB-targeting DARPin MP0310" @default.
- NCIT_C170894 NCIT_P208 "CL1383054" @default.
- NCIT_C170894 NCIT_P322 "GDC" @default.
- NCIT_C170894 NCIT_P329 "800803" @default.
- NCIT_C170894 NCIT_P330 "800803" @default.
- NCIT_C170894 NCIT_P375 "FAP/4-1BB-targeting DARPin MP0310" @default.
- NCIT_C170894 NCIT_P399 "800803" @default.
- NCIT_C170894 normalizedInformationContent "100" @default.
- NCIT_C170894 referenceCount "1" @default.
- NCIT_C170894 hasExactSynonym "AMG 506" @default.
- NCIT_C170894 hasExactSynonym "FAP x 4-1BB-targeting DARPin MP0310" @default.
- NCIT_C170894 hasExactSynonym "FAP/4-1BB-targeting DARPin MP0310" @default.
- NCIT_C170894 hasExactSynonym "FAP/4-1BB-targeting Designed Ankyrin Repeat Protein MP0310" @default.
- NCIT_C170894 hasExactSynonym "MP 0310" @default.
- NCIT_C170894 hasExactSynonym "MP-0310" @default.
- NCIT_C170894 hasExactSynonym "MP0310" @default.
- NCIT_C170894 inSubset NCIT_C128784 @default.
- NCIT_C170894 inSubset NCIT_C157711 @default.
- NCIT_C170894 inSubset NCIT_C157712 @default.
- NCIT_C170894 inSubset NCIT_C176424 @default.
- NCIT_C170894 inSubset NCIT_C177537 @default.
- NCIT_C170894 type Class @default.
- NCIT_C170894 isDefinedBy ncit.owl @default.
- NCIT_C170894 label "FAP/4-1BB-targeting DARPin MP0310" @default.
- NCIT_C170894 subClassOf NCIT_C129820 @default.
- NCIT_C170894 subClassOf NCIT_C170894 @default.
- NCIT_C170894 subClassOf NCIT_C1908 @default.
- NCIT_C170894 subClassOf NCIT_C1909 @default.
- NCIT_C170894 subClassOf NCIT_C274 @default.
- NCIT_C170894 subClassOf NCIT_C308 @default.