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- NCIT_C170900 IAO_0000115 "An orally available, small molecule inhibitor of the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential immune checkpoint inhibitory, anti-viral and antineoplastic activities. Upon administration, PD-L1 inhibitor GS-4224 specifically targets PD-L1 expressed on tumor cells preventing the binding and subsequent activation of its receptor, programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1). This reverses T-cell inactivation caused by PD-L1/PD-1 signaling, increases T-cell expansion and enhances the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells. It may also enhance hepatitis B virus (HBV)-specific CD8+ T-cell function, thereby killing HBV-infected cells. PD-L1, a transmembrane protein expressed on activated T-cells, is overexpressed in some cancer types and plays a significant role in immune evasion by tumor cells. It is also upregulated in HBV-positive patients and contributes to immune dysfunction against HBV infection." @default.
- NCIT_C170900 NCIT_A32 NCIT_C1909 @default.
- NCIT_C170900 NCIT_A7 NCIT_C96024 @default.
- NCIT_C170900 NCIT_NHC0 "C170900" @default.
- NCIT_C170900 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C170900 NCIT_P108 "PD-L1 Inhibitor GS-4224" @default.
- NCIT_C170900 NCIT_P208 "CL1383048" @default.
- NCIT_C170900 NCIT_P322 "GDC" @default.
- NCIT_C170900 NCIT_P329 "800806" @default.
- NCIT_C170900 NCIT_P330 "800806" @default.
- NCIT_C170900 NCIT_P375 "PD-L1 Inhibitor GS-4224" @default.
- NCIT_C170900 NCIT_P399 "800806" @default.
- NCIT_C170900 normalizedInformationContent "100" @default.
- NCIT_C170900 referenceCount "1" @default.
- NCIT_C170900 hasExactSynonym "GS 4224" @default.
- NCIT_C170900 hasExactSynonym "GS-4224" @default.
- NCIT_C170900 hasExactSynonym "GS4224" @default.
- NCIT_C170900 hasExactSynonym "PD-1 Ligand 1 Inhibitor GS-4224" @default.
- NCIT_C170900 hasExactSynonym "PD-L1 Inhibitor GS-4224" @default.
- NCIT_C170900 inSubset NCIT_C128784 @default.
- NCIT_C170900 inSubset NCIT_C157711 @default.
- NCIT_C170900 inSubset NCIT_C157712 @default.
- NCIT_C170900 inSubset NCIT_C176424 @default.
- NCIT_C170900 inSubset NCIT_C177537 @default.
- NCIT_C170900 type Class @default.
- NCIT_C170900 isDefinedBy ncit.owl @default.
- NCIT_C170900 label "PD-L1 Inhibitor GS-4224" @default.
- NCIT_C170900 subClassOf NCIT_C141144 @default.
- NCIT_C170900 subClassOf NCIT_C143250 @default.
- NCIT_C170900 subClassOf NCIT_C156893 @default.
- NCIT_C170900 subClassOf NCIT_C163758 @default.
- NCIT_C170900 subClassOf NCIT_C170900 @default.
- NCIT_C170900 subClassOf NCIT_C1908 @default.
- NCIT_C170900 subClassOf NCIT_C1909 @default.
- NCIT_C170900 subClassOf NCIT_C191689 @default.
- NCIT_C170900 subClassOf NCIT_C274 @default.
- NCIT_C170900 subClassOf NCIT_C308 @default.