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- NCIT_C170918 IAO_0000115 "An RNA interference (RNAi) targeting hypoxia-inducible factor 2alpha (HIF-2a), with potential antineoplastic activity. Upon administration, zifcasiran binds to and neutralizes mRNA HIF2a, thereby preventing the production of HIF2a. This may lead to an inhibition of tumor cell proliferation. HIF2a, overexpressed in certain cell types, plays a key role in proliferation, progression and metastasis of tumors." @default.
- NCIT_C170918 NCIT_A32 NCIT_C1909 @default.
- NCIT_C170918 NCIT_A5 NCIT_C190204 @default.
- NCIT_C170918 NCIT_A7 NCIT_C104306 @default.
- NCIT_C170918 NCIT_NHC0 "C170918" @default.
- NCIT_C170918 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C170918 NCIT_P107 "Zifcasiran" @default.
- NCIT_C170918 NCIT_P108 "Zifcasiran" @default.
- NCIT_C170918 NCIT_P208 "CL1383073" @default.
- NCIT_C170918 NCIT_P210 "2437257-11-7" @default.
- NCIT_C170918 NCIT_P319 "5G6HL9K2G4" @default.
- NCIT_C170918 NCIT_P322 "CTRP" @default.
- NCIT_C170918 NCIT_P322 "FDA" @default.
- NCIT_C170918 NCIT_P322 "GDC" @default.
- NCIT_C170918 NCIT_P329 "801198" @default.
- NCIT_C170918 NCIT_P330 "801198" @default.
- NCIT_C170918 NCIT_P375 "HIF2a RNAi ARO-HIF2" @default.
- NCIT_C170918 NCIT_P399 "801198" @default.
- NCIT_C170918 normalizedInformationContent "100" @default.
- NCIT_C170918 referenceCount "1" @default.
- NCIT_C170918 hasExactSynonym "ADS-007" @default.
- NCIT_C170918 hasExactSynonym "ARO HIF2" @default.
- NCIT_C170918 hasExactSynonym "ARO-HIF2" @default.
- NCIT_C170918 hasExactSynonym "AROHIF2" @default.
- NCIT_C170918 hasExactSynonym "HIF2a RNAi ARO-HIF2" @default.
- NCIT_C170918 hasExactSynonym "RNA Interference Therapeutic ARO-HIF2" @default.
- NCIT_C170918 hasExactSynonym "TRiM ARO-HIF2" @default.
- NCIT_C170918 hasExactSynonym "Targeted RNAi Molecule ARO-HIF2" @default.
- NCIT_C170918 hasExactSynonym "ZIFCASIRAN" @default.
- NCIT_C170918 hasExactSynonym "Zifcasiran" @default.
- NCIT_C170918 inSubset NCIT_C116977 @default.
- NCIT_C170918 inSubset NCIT_C116978 @default.
- NCIT_C170918 inSubset NCIT_C128784 @default.
- NCIT_C170918 inSubset NCIT_C157711 @default.
- NCIT_C170918 inSubset NCIT_C157712 @default.
- NCIT_C170918 inSubset NCIT_C176424 @default.
- NCIT_C170918 inSubset NCIT_C177537 @default.
- NCIT_C170918 inSubset NCIT_C63923 @default.
- NCIT_C170918 type Class @default.
- NCIT_C170918 isDefinedBy ncit.owl @default.
- NCIT_C170918 label "Zifcasiran" @default.
- NCIT_C170918 subClassOf NCIT_C129821 @default.
- NCIT_C170918 subClassOf NCIT_C170918 @default.
- NCIT_C170918 subClassOf NCIT_C1908 @default.
- NCIT_C170918 subClassOf NCIT_C1909 @default.
- NCIT_C170918 subClassOf NCIT_C274 @default.
- NCIT_C170918 subClassOf NCIT_C307 @default.