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- NCIT_C170976 IAO_0000115 "A T-cell re-directing bi-specific biologic composed of a modified form of human T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) preferentially expressed antigen in melanoma (PRAME) and fused to an anti-CD3 single-chain variable fragment (scFv), with potential antineoplastic activity. Upon administration of IMC-F106C, the TCR moiety of this agent targets and binds to PRAME on tumor cells and the anti-CD3 scFv moiety binds to CD3- expressing T-lymphocytes. This selectively cross-links tumor cells and T-lymphocytes and results in a CTL-mediated death of PRAME-expressing tumor cells. The TAA PRAME is overexpressed by a variety of cancer cell types." @default.
- NCIT_C170976 NCIT_A32 NCIT_C1909 @default.
- NCIT_C170976 NCIT_A7 NCIT_C127930 @default.
- NCIT_C170976 NCIT_NHC0 "C170976" @default.
- NCIT_C170976 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C170976 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C170976 NCIT_P107 "Anti-PRAME T-cell Receptor/Anti-CD3 scFv Fusion Protein IMC-F106C" @default.
- NCIT_C170976 NCIT_P108 "Anti-PRAME T-cell Receptor/Anti-CD3 scFv Fusion Protein IMC-F106C" @default.
- NCIT_C170976 NCIT_P208 "CL1383231" @default.
- NCIT_C170976 NCIT_P322 "CTRP" @default.
- NCIT_C170976 NCIT_P322 "GDC" @default.
- NCIT_C170976 NCIT_P329 "801222" @default.
- NCIT_C170976 NCIT_P330 "801222" @default.
- NCIT_C170976 NCIT_P375 "Anti-PRAME T-cell Receptor/Anti-CD3 scFv Fusion Protein IMC-F106C" @default.
- NCIT_C170976 NCIT_P399 "801222" @default.
- NCIT_C170976 NCIT_R124 NCIT_C17710 @default.
- NCIT_C170976 NCIT_R124 NCIT_C17828 @default.
- NCIT_C170976 NCIT_R124 NCIT_C18219 @default.
- NCIT_C170976 NCIT_R124 NCIT_C19986 @default.
- NCIT_C170976 NCIT_R124 NCIT_C40474 @default.
- NCIT_C170976 normalizedInformationContent "100" @default.
- NCIT_C170976 referenceCount "1" @default.
- NCIT_C170976 hasExactSynonym "Anti-PRAME T-cell Receptor/Anti-CD3 scFv Fusion Protein IMC-F106C" @default.
- NCIT_C170976 hasExactSynonym "ImmTAC IMC-F106C" @default.
- NCIT_C170976 hasExactSynonym "ImmTAC Molecule IMC-F106C" @default.
- NCIT_C170976 hasExactSynonym "Immune Mobilizing Monoclonal TCR Against Cancer IMC-F106C" @default.
- NCIT_C170976 inSubset NCIT_C116977 @default.
- NCIT_C170976 inSubset NCIT_C116978 @default.
- NCIT_C170976 inSubset NCIT_C128784 @default.
- NCIT_C170976 inSubset NCIT_C157711 @default.
- NCIT_C170976 inSubset NCIT_C157712 @default.
- NCIT_C170976 inSubset NCIT_C176424 @default.
- NCIT_C170976 inSubset NCIT_C177537 @default.
- NCIT_C170976 type Class @default.
- NCIT_C170976 isDefinedBy ncit.owl @default.
- NCIT_C170976 label "Anti-PRAME T-cell Receptor/Anti-CD3 scFv Fusion Protein IMC-F106C" @default.
- NCIT_C170976 subClassOf NCIT_C170976 @default.
- NCIT_C170976 subClassOf NCIT_C1908 @default.
- NCIT_C170976 subClassOf NCIT_C1909 @default.
- NCIT_C170976 subClassOf NCIT_C20401 @default.
- NCIT_C170976 subClassOf NCIT_C307 @default.
- NCIT_C170976 subClassOf NCIT_C308 @default.