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- NCIT_C171066 IAO_0000115 "A preparation of allogeneic, off-the-shelf, T-lymphocytes that have been genetically modified using a proprietary synthetic nuclease-based system to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-BCMA-CAR T-cells PBCAR269A specifically recognize and kill BCMA-expressing tumor cells. BCMA, a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). BCMA is found on the surfaces of plasma cells, is overexpressed on malignant plasma cells and plays a key role in plasma cell proliferation and survival." @default.
- NCIT_C171066 NCIT_A32 NCIT_C1909 @default.
- NCIT_C171066 NCIT_A7 NCIT_C97848 @default.
- NCIT_C171066 NCIT_NHC0 "C171066" @default.
- NCIT_C171066 NCIT_P106 "Cell" @default.
- NCIT_C171066 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C171066 NCIT_P107 "Allogeneic Anti-BCMA-CAR T-cells PBCAR269A" @default.
- NCIT_C171066 NCIT_P108 "Allogeneic Anti-BCMA-CAR T-cells PBCAR269A" @default.
- NCIT_C171066 NCIT_P208 "CL1405454" @default.
- NCIT_C171066 NCIT_P322 "CTRP" @default.
- NCIT_C171066 NCIT_P322 "GDC" @default.
- NCIT_C171066 NCIT_P329 "801229" @default.
- NCIT_C171066 NCIT_P330 "801229" @default.
- NCIT_C171066 NCIT_P375 "Allogeneic Anti-BCMA-CAR T-cells PBCAR269A" @default.
- NCIT_C171066 NCIT_P399 "801229" @default.
- NCIT_C171066 normalizedInformationContent "100" @default.
- NCIT_C171066 referenceCount "1" @default.
- NCIT_C171066 hasExactSynonym "Allogeneic Anti-BCMA-CAR T-cells PBCAR269A" @default.
- NCIT_C171066 inSubset NCIT_C116977 @default.
- NCIT_C171066 inSubset NCIT_C116978 @default.
- NCIT_C171066 inSubset NCIT_C128784 @default.
- NCIT_C171066 inSubset NCIT_C157711 @default.
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- NCIT_C171066 inSubset NCIT_C176424 @default.
- NCIT_C171066 inSubset NCIT_C177537 @default.
- NCIT_C171066 type Class @default.
- NCIT_C171066 isDefinedBy ncit.owl @default.
- NCIT_C171066 label "Allogeneic Anti-BCMA-CAR T-cells PBCAR269A" @default.
- NCIT_C171066 subClassOf NCIT_C129820 @default.
- NCIT_C171066 subClassOf NCIT_C129821 @default.
- NCIT_C171066 subClassOf NCIT_C129826 @default.
- NCIT_C171066 subClassOf NCIT_C137999 @default.
- NCIT_C171066 subClassOf NCIT_C142078 @default.
- NCIT_C171066 subClassOf NCIT_C154231 @default.
- NCIT_C171066 subClassOf NCIT_C171066 @default.
- NCIT_C171066 subClassOf NCIT_C176023 @default.
- NCIT_C171066 subClassOf NCIT_C1908 @default.
- NCIT_C171066 subClassOf NCIT_C1909 @default.
- NCIT_C171066 subClassOf NCIT_C1962 @default.
- NCIT_C171066 subClassOf NCIT_C200765 @default.
- NCIT_C171066 subClassOf NCIT_C274 @default.
- NCIT_C171066 subClassOf NCIT_C28676 @default.
- NCIT_C171066 subClassOf NCIT_C307 @default.
- NCIT_C171066 subClassOf NCIT_C308 @default.