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- NCIT_C171161 IAO_0000115 "A bispecific antibody that simultaneously binds to two different and as of yet undisclosed antigens co-expressed specifically on tumor-infiltrating regulatory T-cells (Tregs), with potential immunomodulating and antineoplastic activities. Upon administration, AGEN1223 targets and binds to the two antigens co-expressed specifically on tumor-infiltrating Tregs. This leads to the selective depletion of immunosuppressive Tregs in the tumor microenvironment (TME), while sparing peripheral Tregs and effector T-cells, enhancing the overall antitumor response. AGEN1223 may also co-stimulate antigen-specific effector T-cells, resulting in tumor cell death." @default.
- NCIT_C171161 NCIT_A32 NCIT_C1909 @default.
- NCIT_C171161 NCIT_NHC0 "C171161" @default.
- NCIT_C171161 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C171161 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C171161 NCIT_P107 "Bispecific Antibody AGEN1223" @default.
- NCIT_C171161 NCIT_P108 "Bispecific Antibody AGEN1223" @default.
- NCIT_C171161 NCIT_P208 "CL1405398" @default.
- NCIT_C171161 NCIT_P322 "CTRP" @default.
- NCIT_C171161 NCIT_P322 "GDC" @default.
- NCIT_C171161 NCIT_P329 "801965" @default.
- NCIT_C171161 NCIT_P330 "801965" @default.
- NCIT_C171161 NCIT_P375 "Bispecific Antibody AGEN1223" @default.
- NCIT_C171161 NCIT_P399 "801965" @default.
- NCIT_C171161 normalizedInformationContent "100" @default.
- NCIT_C171161 referenceCount "1" @default.
- NCIT_C171161 hasExactSynonym "AGEN 1223" @default.
- NCIT_C171161 hasExactSynonym "AGEN-1223" @default.
- NCIT_C171161 hasExactSynonym "AGEN1223" @default.
- NCIT_C171161 hasExactSynonym "Bispecific Antibody AGEN1223" @default.
- NCIT_C171161 inSubset NCIT_C116977 @default.
- NCIT_C171161 inSubset NCIT_C116978 @default.
- NCIT_C171161 inSubset NCIT_C128784 @default.
- NCIT_C171161 inSubset NCIT_C157711 @default.
- NCIT_C171161 inSubset NCIT_C157712 @default.
- NCIT_C171161 inSubset NCIT_C176424 @default.
- NCIT_C171161 inSubset NCIT_C177537 @default.
- NCIT_C171161 type Class @default.
- NCIT_C171161 isDefinedBy ncit.owl @default.
- NCIT_C171161 label "Bispecific Antibody AGEN1223" @default.
- NCIT_C171161 subClassOf NCIT_C1454 @default.
- NCIT_C171161 subClassOf NCIT_C171161 @default.
- NCIT_C171161 subClassOf NCIT_C1908 @default.
- NCIT_C171161 subClassOf NCIT_C1909 @default.
- NCIT_C171161 subClassOf NCIT_C307 @default.
- NCIT_C171161 subClassOf NCIT_C308 @default.