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- NCIT_C171344 IAO_0000115 "An orally bioavailable, selective inhibitor of cyclin-dependent kinase (CDK) types 4 (CDK4) and 6 (CDK6), with potential antineoplastic activity. Upon oral administration, CDK4/6 inhibitor TQB3616 selectively inhibits CDK4 and CDK6, which inhibits the phosphorylation of retinoblastoma protein (Rb) early in the G1 phase, prevents CDK-mediated G1-S-phase transition and leads to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of both cell cycle progression from the G1-phase into the S-phase and tumor cell proliferation." @default.
- NCIT_C171344 NCIT_A32 NCIT_C1909 @default.
- NCIT_C171344 NCIT_NHC0 "C171344" @default.
- NCIT_C171344 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C171344 NCIT_P108 "CDK4/6 Inhibitor TQB3616" @default.
- NCIT_C171344 NCIT_P208 "CL1405461" @default.
- NCIT_C171344 NCIT_P322 "GDC" @default.
- NCIT_C171344 NCIT_P329 "801305" @default.
- NCIT_C171344 NCIT_P330 "801305" @default.
- NCIT_C171344 NCIT_P375 "CDK4/6 Inhibitor TQB3616" @default.
- NCIT_C171344 NCIT_P399 "801305" @default.
- NCIT_C171344 normalizedInformationContent "100" @default.
- NCIT_C171344 referenceCount "1" @default.
- NCIT_C171344 hasExactSynonym "CDK4/6 Inhibitor TQB3616" @default.
- NCIT_C171344 hasExactSynonym "TQB 3616" @default.
- NCIT_C171344 hasExactSynonym "TQB-3616" @default.
- NCIT_C171344 hasExactSynonym "TQB3616" @default.
- NCIT_C171344 inSubset NCIT_C128784 @default.
- NCIT_C171344 inSubset NCIT_C157711 @default.
- NCIT_C171344 inSubset NCIT_C157712 @default.
- NCIT_C171344 inSubset NCIT_C176424 @default.
- NCIT_C171344 inSubset NCIT_C177537 @default.
- NCIT_C171344 type Class @default.
- NCIT_C171344 isDefinedBy ncit.owl @default.
- NCIT_C171344 label "CDK4/6 Inhibitor TQB3616" @default.
- NCIT_C171344 subClassOf NCIT_C129824 @default.
- NCIT_C171344 subClassOf NCIT_C129825 @default.
- NCIT_C171344 subClassOf NCIT_C1404 @default.
- NCIT_C171344 subClassOf NCIT_C163758 @default.
- NCIT_C171344 subClassOf NCIT_C171344 @default.
- NCIT_C171344 subClassOf NCIT_C1908 @default.
- NCIT_C171344 subClassOf NCIT_C1909 @default.
- NCIT_C171344 subClassOf NCIT_C192741 @default.
- NCIT_C171344 subClassOf NCIT_C192742 @default.
- NCIT_C171344 subClassOf NCIT_C2185 @default.
- NCIT_C171344 subClassOf NCIT_C2189 @default.
- NCIT_C171344 subClassOf NCIT_C274 @default.
- NCIT_C171344 subClassOf NCIT_C471 @default.
- NCIT_C171344 subClassOf NCIT_C61074 @default.